A mathematical model for predicting the adult height of girls with advanced puberty after spontaneous growth

Autor: Raja Brauner, Delphine Pierre, Jean-Baptiste Bertrand, Pierre Lemaire
Přispěvatelé: Recherche Opérationnelle pour les Systèmes de Production (G-SCOP_ROSP), Laboratoire des sciences pour la conception, l'optimisation et la production (G-SCOP), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes - Paris 5 (UPD5), ROSP (G-SCOP_ROSP), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National Polytechnique de Grenoble (INPG)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National Polytechnique de Grenoble (INPG)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS), ROSP ( G-SCOP_ROSP ), Laboratoire des sciences pour la conception, l'optimisation et la production ( G-SCOP ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut polytechnique de Grenoble - Grenoble Institute of Technology ( Grenoble INP ) -Institut National Polytechnique de Grenoble ( INPG ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ) -Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut polytechnique de Grenoble - Grenoble Institute of Technology ( Grenoble INP ) -Institut National Polytechnique de Grenoble ( INPG ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ), Université Paris Descartes - Paris 5 ( UPD5 )
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Adult
medicine.medical_specialty
Pediatrics
Pubic hair stage
Adolescent
Body height
[ SDV.MHEP.PED ] Life Sciences [q-bio]/Human health and pathology/Pediatrics
Puberty
Precocious
030209 endocrinology & metabolism
Models
Biological
Paternal transmission
03 medical and health sciences
0302 clinical medicine
[MATH.MATH-ST]Mathematics [math]/Statistics [math.ST]
030225 pediatrics
medicine
Humans
[ MATH.MATH-ST ] Mathematics [math]/Statistics [math.ST]
Pediatrics
Perinatology
and Child Health
Child
Retrospective Studies
Gynecology
[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics
business.industry
Follow up studies
Bone age
[STAT.TH]Statistics [stat]/Statistics Theory [stat.TH]
[ SDV.MHEP.EM ] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism
[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism
[ STAT.TH ] Statistics [stat]/Statistics Theory [stat.TH]
Adult height
Body Height
Pediatrics
Perinatology and Child Health
Linear Models
Female
business
Research Article
Follow-Up Studies
Zdroj: BMC Pediatrics
BMC Pediatrics, BioMed Central, 2014, 14, pp.172. ⟨10.1186/1471-2431-14-172⟩
BMC Pediatrics, BioMed Central, 2014, 14, pp.172. 〈10.1186/1471-2431-14-172〉
ISSN: 1471-2431
DOI: 10.1186/1471-2431-14-172⟩
Popis: International audience; BACKGROUND: Advanced puberty in girls is defined as the onset of puberty between the ages of 8 yr and 10 yr. The objective was to predict adult height (AH) at initial evaluation and to characterize patients with an actual AH below -2 SD (152 cm) and/or lower than their target height (TH) by > one SD (5.6 cm). METHODS: Data analysis using multiple linear regression models was performed in 50 girls with advanced puberty who reached their AH after spontaneous puberty. RESULTS: The actual AH (159.0 ± 6.1 cm) was similar to the TH (161.2 ± 4.6 cm) and to the AH predicted at the initial evaluation (160.8 ± 6.0 cm), and the actual AH correlated positively with both (R = 0.76, P = 0.0003; R = 0.71, P = 0.008, respectively).The AH was below 152 cm in 7 girls, of whom 3 were characterized by paternal transmission of the advanced puberty. The AH was lower than the TH by >5.6 cm in 8 girls.The AH (cm) could be calculated at the initial evaluation: 1.8822 age + 3.3510 height (SD) - 0.7465 bone age - 1.7993 pubic hair stage + 2.8409 TH (SD) + 150.32.The formula is available online at http://www.kamick.org/lemaire/med/girls-advpub.html.The calculated AH (159.0 ± 5.7 cm) and the actual AH were highly correlated (R = 0.93). The actual AH was lower than the calculated AH by > 0.5 SD in only one case (4.35 cm). CONCLUSION: We established a formula that can be used at an initial evaluation to predict the AH, and then to assess the risk of reduced AH as a result of advanced puberty. According to this formula, the actual AH was lower than the calculated AH by more than 2.8 cm (0.5 SD) in only one girl. The AHs of the untreated girls with advanced puberty did not differ from those predicted at the initial evaluation by the Bayley and Pinneau table or from the THs. However, this study provides a useful and ready-to-use formula that can be an additional assessment of girls with advanced puberty.
Databáze: OpenAIRE
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