Headache: an important symptom possibly linked to white matter lesions in thalassaemia
| Autor: | David J. Weatherall, Shantha Hettiarachchi, Nizri Hameed, Taraka Pilapitiya, Gihan Weerasinghe, Nancy F. Olivieri, Ishari Silva, Arunasalam Pathmeswaran, Udaya K. Ranawaka, A. Hapangama, K.A. Salvin, Mark W Weatherall, Anuja Premawardhena |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty β thalassaemia Gastroenterology 03 medical and health sciences 0302 clinical medicine Cognition Older patients hemic and lymphatic diseases Internal medicine Medicine Humans In patient Child Stroke Sri Lanka medicine.diagnostic_test business.industry beta-Thalassemia Thalassaemia intermedia Headache Infant Magnetic resonance imaging Hematology medicine.disease Magnetic Resonance Imaging White Matter Hyperintensity 030220 oncology & carcinogenesis Child Preschool Female Headaches medicine.symptom business 030215 immunology |
| Zdroj: | British journal of haematology. 185(3) |
| ISSN: | 1365-2141 |
| Popis: | Neurological manifestations are reported only occasionally in patients with thalassaemia and are given much less prominence than the complications related to anaemia and iron overload. White matter changes (WMCs) on magnetic resonance imaging (MRI) in patients with thalassaemia were first reported two decades ago but the significance of these lesions remains unclear. We studied the neurological and cognitive manifestations in 82 older patients with thalssaemia [25 Thalassaemia major (TM), 24 thalassaemia intermedia (TI) and 33 haemaglobin E β thalassaemia (EBT)] and 80 controls, and found that headaches were more common in thalassaemia patients (50/82, 61%) than in controls (18/80, 22·5%: P < 0·001). WMCs on MRI were found in 20/82 (24·3%) patients and 2/29 (6·9%) controls had (P = 0·078). WMC were more common among those with headaches (17/50: 34%) than in those without headache (3/32; 9·3%) (P = 0·023). WMCs were not associated with reduction of cognition. Nevertheless, cognition was lower in the TI and EBT groups compared with those with TM (P = 0·002). The association of headache with WMC in thalassaemia has not been reported before and warrants further study. |
| Databáze: | OpenAIRE |
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