Physicochemical characterisation of mangafodipir trisodium
| Autor: | C.E. Sjøgren, E. Couture, K. M. Holm, H. Sivertsen Lunde, Åsmund Larsen, Audun Aukrust, H. Hope, Birgit Tirkkonen, D. Grace, Y. Haile |
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| Rok vydání: | 1997 |
| Předmět: |
Chemical Phenomena
Contrast Media Infrared spectroscopy Crystallography X-Ray law.invention Metal chemistry.chemical_compound Nuclear magnetic resonance law Molecule Medicine Radiology Nuclear Medicine and imaging Carboxylate Crystallization Edetic Acid Coordination geometry Manganese Molecular Structure Radiological and Ultrasound Technology Chemistry Physical business.industry Spectrum Analysis General Medicine Solutions Crystallography Octahedron chemistry Polymorphism (materials science) Pyridoxal Phosphate visual_art visual_art.visual_art_medium business |
| Zdroj: | Acta Radiologica. 38:780-789 |
| ISSN: | 0284-1851 |
| DOI: | 10.3109/02841859709172411 |
| Popis: | Purpose: To determine the structure and various physicochemical properties of man-gafodipir (MnDPDP) trisodium, the active ingredient of Teslascan, a new organ-specific contrast medium for MR imaging. Material and Methods: The structure of MnDPDP trisodium crystals was determined by X-ray crystallography. The possible existence of polymorphism in MnDPDP trisodium was evaluated by powder X-ray diffraction, optical microscopy, thermal analysis and IR spectroscopy. In addition, various spectroscopic techniques and physicochemical measurements were used for characterisation of MnDPDP trisodium. Results: The crystallographic data obtained for MnDPDP trisodium show that the general core structure of the MnDPDP anion is similar to that seen in related substances. The metal coordination geometry is a distorted octahedron defined by 2 phenolate oxygens, 2 carboxylate oxygens and 2 amine nitrogens. The unit cell contains 2 MnDPDP anions, 6 sodium ions and 50 water molecules. The various spectroscopic data are consistent with the structure determined by X-ray crystallography. The product (Teslascan) has low viscosity, is isotonic with blood and has a physiological pH. Conclusion: MnDPDP trisodium is a crystalline, hygroscopic solid which is readily soluble in water. No evidence of polymorphism was seen in the samples studied. |
| Databáze: | OpenAIRE |
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