Patterns of spinal cord atrophy in HTLV-1 associated myelopathy/ tropical spastic paraparesis (HAM/TSP)
| Autor: | Breanna Caruso, Steven Jacobson, Raya Massoud, Govind Nair, Joan Ohayon, Emily Charlip, Winston Liu, Jeanne Billioux |
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| Rok vydání: | 2015 |
| Předmět: |
Pathology
medicine.medical_specialty Cord Spinal cord atrophy business.industry Surrogate endpoint virus diseases HTLV 1-associated myelopathy medicine.disease Spinal cord Infectious Diseases Atrophy medicine.anatomical_structure immune system diseases Virology Poster Presentation Tropical spastic paraparesis medicine business Asymptomatic carrier |
| Zdroj: | Retrovirology |
| ISSN: | 1742-4690 |
| DOI: | 10.1186/1742-4690-12-s1-p32 |
| Popis: | Spinal cord inflammation and atrophy contribute to debilitating symptoms in HAM/TSP. We have developed a robust and fast algorithm to determine average cross-sectional area in cervical (c-spine) and thoracic (t-spine) spinal cords by tracing contours perpendicular to the edge in T1-weighted MRI images. The cross-sectional areas in the c- and t-spines were determined in 25 HAM/TSP, 10 asymptomatic carriers (AC) and 10 healthy volunteer (HV) subjects. To date, we have followed 8 of the HAM/TSP patients longitudinally over a two-year period. When compared to the HV data, the HAM/TSP spinal cord profiles fell into four general categories: atrophic entire spine (48%), atrophic t-spine (32%), atrophic c-spine (8%), and normal (12%). The majority of ACs had similar spinal cord profiles to those in the HV group, however, 3 ACs showed a pattern similar to HAM/TSP. As a group, both HAM/TSP c- and t-spines were significantly lower than those of HV (p |
| Databáze: | OpenAIRE |
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