Evaluating Antitumor and Antioxidant Activities of Yellow Monascus Pigments from Monascus ruber Fermentation

Autor: Xiaofei Tian, Hailing Tan, Ziyi Xing, Zhenqiang Wu, Gong Chen
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Vascular Endothelial Growth Factor A
0301 basic medicine
Monascus ruber
Antioxidant
medicine.medical_treatment
Pharmaceutical Science
Orange (colour)
migration
Antioxidants
Analytical Chemistry
Cell Movement
Drug Discovery
Food science
MCF-7 cells
Incubation
natural yellow Monascus pigments
Cell Death
biology
Chemistry
Free Radical Scavengers
Monascus
invasion
Matrix Metalloproteinase 9
Chemistry (miscellaneous)
antioxidation
visual_art
visual_art.visual_art_medium
Matrix Metalloproteinase 2
Molecular Medicine
Antineoplastic Agents
Article
lcsh:QD241-441
03 medical and health sciences
Pigment
Picrates
lcsh:Organic chemistry
medicine
Humans
Neoplasm Invasiveness
Benzothiazoles
Physical and Theoretical Chemistry
Cell Proliferation
Cell growth
Biphenyl Compounds
Organic Chemistry
Water
water-soluble
Pigments
Biological
biology.organism_classification
030104 developmental biology
Solubility
Fermentation
Sulfonic Acids
Zdroj: Molecules
Volume 23
Issue 12
Molecules, Vol 23, Iss 12, p 3242 (2018)
ISSN: 1420-3049
DOI: 10.3390/molecules23123242
Popis: Yellow Monascus pigments can be of two kinds: Natural and reduced, in which natural yellow Monascus pigments (NYMPs) attract widespread attention for their bioactivities. In this study, the antioxidative and antibreast cancer effects of the water-soluble NYMPs fermented by Monascus ruber CGMCC 10910 were evaluated. Results showed that water-soluble NYMPs had a significantly improved antioxidative activities compared to the reduced yellow Monascus pigments (RYMPs) that were chemically derived from orange or red Monascus pigments. Furthermore, NYMPs exhibited a concentration-dependent inhibition activity on MCF-7 cell growth (p <
0.001). After a 48-h incubation, a 26.52% inhibition yield was determined with 32 &mu
g/mL of NYMPs. NYMPs also significantly inhibited the migration and invasion of MCF-7 cells. Mechanisms of the activities were associated with a down-regulation of the expression of matrix metalloproteinases and vascular endothelial growth factor. Rather than being alternatively used as natural colorants or antioxidants, this work suggested that NYMPs could be selected as potential functional additives in further test of breast cancer prevention and adjuvant therapy.
Databáze: OpenAIRE
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