| Autor: |
Lucyana LC Coutinho, Caroline N Oliveira, Polianna LMM Albuquerque, Sandra MB Mota, Gdayllon C Meneses, Alice MC Martins, Geraldo BS Junior, Marco AF Clementino, Rafhaella NDG Gondim, Alexandre Havt, Luciano PG Cavalcanti, Juliana NU Yaochite |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Future microbiology. 17 |
| ISSN: |
1746-0921 |
| Popis: |
Background: A dysregulated inflammatory response contributes to decline in patients with COVID-19. This cross-sectional study evaluated biomarkers of unvaccinated patients admitted to the intensive care unit of a hospital in Fortaleza, Brazil. Methods: Twenty cytokines were quantified upon hospital admission; clinical and laboratory data were analyzed, as well as sociodemographic data, to search for an association with clinical outcomes, including fatal (n = 40) or recovered cases (n = 38). Results: Fatal cases exhibited significantly higher levels of IL-18 (p = 0.009); deceased patients were older (p = 0.0001), had a lower number of platelets (p = 0.0063) and higher neutrophil–lymphocyte ratio (p = 0.0230) than those who recovered. Conclusion: These findings indicate that IL-18 is a possible marker to predict poor prognosis in critically ill patients with COVID-19. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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