Phosphonium‐Ring‐Fused Bicyclic Metallafuran Complexes of Ruthenium and Osmium

Autor:	Man-Kit Tse, Siu-Chung Chan, Shek-Man Yiu, Sheung-Ying Tse, Chi-Fung Yeung, Chun-Yuen Wong, Sze-Wing Ng, Hau-Lam Shek, Lai-Hon Chung
Rok vydání:	2019
Předmět:	Bicyclic molecule 010405 organic chemistry Stereochemistry Organic Chemistry Rational design chemistry.chemical_element General Chemistry 010402 general chemistry Ring (chemistry) 01 natural sciences Catalysis 0104 chemical sciences Ruthenium Metal chemistry.chemical_compound chemistry visual_art visual_art.visual_art_medium Osmium Phosphonium Cytotoxicity
Zdroj:	Chemistry – A European Journal. 25:9159-9163
ISSN:	1521-3765 0947-6539
Popis:	Metallafuran complexes with a fused five-membered phosphonium ring were synthesized from reactions between terminal ynones HC≡C(C=O)R and cis-[Ru/Os(dppm)2 Cl2 ] (dppm=1,1-bis(diphenylphosphino)methane). A metal-vinylidene-involving pathway was found to be an energetically feasible formation mechanism for these complexes. These phosphonium-containing metallafurans, like many phosphonium-functionalized drugs, have the ability to induce mitochondrial dysfunction. They also exhibit stronger cytotoxicity against several human cancer cell lines in comparison with their metal precursors and the classic anticancer drug cisplatin. Overall, this work provides structural and mechanistic insights for the rational design of functional metallacycles via activation of alkynes by RuII and OsII centers.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67fbce6e2a4cf9062f2935e901633137 https://doi.org/10.1002/chem.201901080 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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