Advances and highlights in biomarkers of allergic diseases
| Autor: | Pattraporn Satitsuksanoa, Katja Baerenfaller, Manal Bel Imam, Yasutaka Mitamura, Arturo Rinaldi, Ruben Fernandez-Santamaria, Stephan R Schneider, Luo Zhang, Elena Barletta, Jana Koch, Willem van de Veen, Urszula Radzikowska, Damir Zhakparov, Alexandra Wallimann, Siyuan Ma, Ismail Ogulur, Lacin Cevhertas, Mengting Huang, Ya-Qi Peng, Ozge Ardicli, Marie-Charlotte Brüggen, Debbie J Maurer, Reihane Ziadlou, Yagiz Pat, Juan Rodríguez-Coira, Milena Sokolowska, Mübeccel Akdis, Cezmi A. Akdis |
|---|---|
| Přispěvatelé: | University of Zurich, Akdis, Cezmi A |
| Rok vydání: | 2021 |
| Předmět: |
Allergy
Allergen immunotherapy allergic diseases precision medicine Immunology 610 Medicine & health Disease 10183 Swiss Institute of Allergy and Asthma Research medicine Hypersensitivity Immunology and Allergy Humans Lymphocytes Pandemics Asthma 2403 Immunology business.industry SARS-CoV-2 Innate lymphoid cell 10177 Dermatology Clinic biomarkers COVID-19 medicine.disease Precision medicine Rhinitis Allergic Immunity Innate Exhaled nitric oxide 2723 Immunology and Allergy allergen immunotherapy business Anaphylaxis Biomarkers |
| Zdroj: | Allergy. 76(12) |
| ISSN: | 1398-9995 |
| Popis: | Allergic diseases include asthma, atopic-dermatitis, allergic-rhinitis, drug hypersensitivity and food-allergy. During the past years, there has been a global outbreak of allergic diseases, presenting a considerable medical and socioeconomical-burden. A large fraction of allergic diseases is characterized by a type-2 immune response involving Th2 cells, type-2 innate lymphoid cells, eosinophils, mast cells, and M2 macrophages. Biomarkers are valuable parameters for precision medicine as they provide information on the disease endotypes, clusters, precision diagnoses, identification of therapeutic targets, and monitoring of treatment efficacies. The availability of powerful omics technologies, together with integrated data analysis and network-based approaches can help the identification of clinically useful biomarkers. These biomarkers need to be accurately quantified using robust and reproducible methods, such as reliable and point-of-care systems. Ideally, samples should be collected using quick, cost-efficient and non-invasive methods. In recent years, a plethora of research has been directed towards finding novel biomarkers of allergic diseases. Promising biomarkers of type-2 allergic diseases include sputum eosinophils, serum periostin and exhaled nitric-oxide. Several other biomarkers, such as pro-inflammatory mediators, miRNAs, eicosanoid molecules, epithelial barrier integrity, and microbiota changes are useful for diagnosis and monitoring of allergic diseases and can be quantified in serum, body-fluids and exhaled-air. Herein, we review recent studies on biomarkers for the diagnosis and treatment of asthma, chronic-urticaria, atopic-dermatitis, allergic-rhinitis, chronic-rhinosinusitis, food-allergies, anaphylaxis, drug hypersensitivity and allergen-immunotherapy. In addition, we discuss COVID-19 and allergic diseases within the perspective of biomarkers and recommendations on the management of allergic and asthmatic patients during the COVID-19 pandemic. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text