Prevalence and characteristics of self-reported hypothyroidism and its association with nonorgan-specific manifestations in US sarcoidosis patients: a nationwide registry study
| Autor: | Bara Alzghoul, Tamara Al-Hakim, Mamoun T. Mardini, Whitney W. Woodmansee, Noopur Singh, Farah Amer, Ayoub Innabi, Diana Barb, Mindy Buchanan, Lisa A. Maier, Leslie Serchuck, Bashar Alzghoul, Diana Gomez Manjarres, Divya Patel, Chen Bai |
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| Rok vydání: | 2020 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Population lcsh:Medicine Logistic regression Interstitial Lung Disease 03 medical and health sciences 0302 clinical medicine Fibromyalgia Internal medicine medicine Chronic fatigue syndrome 030212 general & internal medicine education Depression (differential diagnoses) education.field_of_study business.industry lcsh:R Odds ratio Original Articles medicine.disease Comorbidity 030228 respiratory system Sarcoidosis business |
| Zdroj: | ERJ Open Research article-version (VoR) Version of Record ERJ Open Research, Vol 7, Iss 1 (2021) |
| ISSN: | 2312-0541 |
| Popis: | Little is known about the prevalence, clinical characteristics and impact of hypothyroidism in patients with sarcoidosis. We aimed to determine the prevalence and clinical features of hypothyroidism and its relation to organ involvement and other clinical manifestations in patients with sarcoidosis. We conducted a national registry-based study investigating 3835 respondents to the Sarcoidosis Advanced Registry for Cures Questionnaire between June 2014 and August 2019. This registry is based on a self-reported, web-based questionnaire that provides data related to demographics, diagnostics, sarcoidosis manifestations and treatment. We compared sarcoidosis patients with and without self-reported hypothyroidism. We used multivariable logistic regression and adjusted for potential confounders to determine the association of hypothyroidism with nonorgan-specific manifestations. 14% of the sarcoidosis patients self-reported hypothyroidism and were generally middle-aged white women. Hypothyroid patients had more comorbid conditions and were more likely to have multiorgan sarcoidosis involvement, especially with cutaneous, ocular, joints, liver and lacrimal gland involvement. Self-reported hypothyroidism was associated with depression (adjusted odds ratio (aOR) 1.3, 95% CI 1.01–1.6), antidepressant use (aOR 1.3, 95% CI 1.1–1.7), obesity (aOR 1.7, 95% CI 1.4–2.1), sleep apnoea (aOR 1.7, 95% CI 1.3–2.2), chronic fatigue syndrome (aOR 1.5, 95% CI 1.2–2) and was borderline associated with fibromyalgia (aOR 1.3, 95% CI 1–1.8). Physical impairment was more common in patients with hypothyroidism. Hypothyroidism is a frequent comorbidity in sarcoidosis patients that might be a potentially reversible contributor to fatigue, depression and physical impairment in this population. We recommend considering routine screening for hypothyroidism in sarcoidosis patients especially in those with multiorgan sarcoidosis, fatigue and depression. Hypothyroidism is a frequent comorbidity in sarcoidosis patients, is often associated with sarcoidosis multiorgan involvement, and might be a potentially reversible contributor to fatigue, depression and physical impairment in this population https://bit.ly/2XGdjKg |
| Databáze: | OpenAIRE |
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