Visceral fat-related systemic inflammation and the adolescent brain: a mediating role of circulating glycerophosphocholines
| Autor: | Catriona Syme, Tomáš Paus, Graeme P. Taylor, Gabriel Leonard, Hongbin Xu, Lisa J. Strug, Michel Perron, Daniel Gaudet, Bruce Pike, Suzanne Veillette, Michal Abrahamowicz, Yun Wang, Jean Shin, Steffany A. L. Bennett, Louis Richer, Stephanie Pelletier, Zdenka Pausova |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Pediatric Obesity medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Medicine (miscellaneous) Brain Structure and Function Neuroimaging 030209 endocrinology & metabolism Inflammation Intra-Abdominal Fat Systemic inflammation 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans 030212 general & internal medicine Cognitive impairment Visceral fat Adiposity Nutrition and Dietetics medicine.diagnostic_test business.industry Brain Magnetic resonance imaging Magnetic Resonance Imaging Peripheral Cross-Sectional Studies Endocrinology Glycerophosphates Female medicine.symptom business |
| Zdroj: | International Journal of Obesity. 43:1223-1230 |
| ISSN: | 1476-5497 0307-0565 |
| Popis: | Life-long maintenance of brain health is important for the prevention of cognitive impairment in older age. Low-grade peripheral inflammation associated with excess visceral fat (VF) may influence brain structure and function. Here we examined (i) if this type of inflammation is associated with altered white-matter (WM) microstructure and lower cognitive functioning in adolescents, and (ii) if recently identified circulating glycerophosphocholines (GPCs) can index this type of inflammation and associated variations in WM microstructure and cognitive functioning. We studied a community-based sample of 872 adolescents (12–18 years, 48% males) in whom we assessed VF and WM microstructure with magnetic resonance imaging, processing speed with cognitive testing, serum C-reactive protein (CRP, a common marker of peripheral inflammation) with a high-sensitivity assay, and serum levels of a panel of 64 GPCs with advanced mass spectrometry. VF was associated with CRP, and CRP in turn was associated with “altered” WM microstructure and lower processing speed (all p |
| Databáze: | OpenAIRE |
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