New cytotoxic phloroglucinol derivatives from Agrimonia pilosa
| Autor: | Zha-Jun Zhan, Lulu Fu, Chenghua Lu, Xiao-Rong Hou, Wei-Guang Shan, Lan Tang |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Stereochemistry Phloroglucinol Positive control Agrimonia 010402 general chemistry 01 natural sciences 03 medical and health sciences chemistry.chemical_compound X-Ray Diffraction Cell Line Tumor Drug Discovery Organic chemistry Cytotoxic T cell Humans Cytotoxicity Pharmacology biology Molecular Structure General Medicine biology.organism_classification Antineoplastic Agents Phytogenic Agrimonia pilosa 0104 chemical sciences 030104 developmental biology chemistry |
| Zdroj: | Fitoterapia. 118 |
| ISSN: | 1873-6971 |
| Popis: | Three new phloroglucinol derivatives, namely agripinol A-C (1-3), were isolated from Agrimonia pilosa Ledeb, along with two known ones (4-5). Their structures were characterized by spectroscopic methods, including MS and NMR spectroscopic techniques. The absolute configurations of the new compounds were unambiguously established by single crystal X-ray diffraction analyses. In the cytotoxicity assay, all compounds exhibited more potent cytotoxic activities against HCT-116, MDA-MB-231 and PC-3, as compared with the positive control fluorouracil. |
| Databáze: | OpenAIRE |
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