Atheroprotective Effects of Bilberry Extracts in Apo E-Deficient Mice
| Autor: | F. Michel, Dragan Milenkovic, Christine Morand, Augustin Scalbert, Aurelie Mauray, Andrzej Mazur, Nelly Caccia, Catherine Felgines, Catherine Besson |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Apolipoprotein E Bilberry Apolipoprotein B Ratón Flavonoid Vaccinium myrtillus Biology Pharmacology Protective Agents medicine.disease_cause Mice Random Allocation chemistry.chemical_compound Apolipoproteins E medicine Animals Humans Mice Knockout chemistry.chemical_classification Plant Extracts General Chemistry Atherosclerosis biology.organism_classification Disease Models Animal Oxidative Stress chemistry Biochemistry Anthocyanin biology.protein General Agricultural and Biological Sciences Oxidative stress |
| Zdroj: | Journal of Agricultural and Food Chemistry. 57:11106-11111 |
| ISSN: | 1520-5118 0021-8561 |
| DOI: | 10.1021/jf9035468 |
| Popis: | Previous studies have demonstrated that the intake of berry foods was associated with a reduced risk of cardiovascular diseases. The aim of the present study was to evaluate the effects of two bilberry extracts, one rich in anthocyanins extracted from untreated bilberries (BE) and a second one extracted from yeast-fermented bilberries (FBE), on the development of atherosclerosis in apolipoprotein E-deficient mice (apo E(-/-)). Apo E(-/-) mice received for 16 weeks a diet supplemented with 0.02% of either BE or FBE. Atherosclerotic plaque area was measured in the aortic sinus. Supplementation of the diet with both bilberry extracts led to a significant inhibition of plaque development, whereas no effect on oxidative stress parameters or lipid profiles could be observed, suggesting the implication of other mechanisms of action. In addition, a better protection was observed with FBE, suggesting that the fermentation generates new bioactive compounds more effective in attenuating progression of the atherosclerotic lesions. |
| Databáze: | OpenAIRE |
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