Induced hypothermia is associated with reduced circulating subunits of mitochondrial DNA in cardiac arrest patients
| Autor: | Hamid Aslami, Anita M Tuip, Janneke Horn, Nicole P. Juffermans, Charlotte J. P. Beurskens |
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| Přispěvatelé: | Anesthesiology, Other departments, ACS - Heart failure & arrhythmias, ANS - Neuroinfection & -inflammation, Intensive Care Medicine |
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Mitochondrial DNA medicine.medical_treatment Ischemia Mitochondrion Biology DNA Mitochondrial Body Temperature law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial Hypothermia Induced law Internal medicine Genetics medicine Humans In patient 030212 general & internal medicine Cardiopulmonary resuscitation Molecular Biology 030208 emergency & critical care medicine Middle Aged Hypothermia Prognosis medicine.disease Endocrinology Case-Control Studies Female medicine.symptom Reperfusion injury Out-of-Hospital Cardiac Arrest |
| Zdroj: | Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis, 29(4), 525-528. Taylor and Francis Ltd. |
| ISSN: | 2470-1408 2470-1394 |
| DOI: | 10.1080/24701394.2017.1315568 |
| Popis: | Induced hypothermia may protect from ischemia reperfusion injury. The mechanism of protection is not fully understood and may include an effect on mitochondria. Here we describe the effect of hypothermia on circulating mitochondrial (mt) DNA in a substudy of a multicenter randomized trial (the Target Temperature Management trial). Circulating levels of mtDNA were elevated in patients with cardiac arrest at all-time points compared to healthy controls. After 24 h of temperature management, patients kept at 33 °C had significantly lower levels of COX3, NADH1 and NADH2 compared to baseline, in contrast to those kept at 36 °C. After regain of temperature, cytochrome – B was significantly reduced in patients kept at 33 °C with cardiac arrest. Cardiac arrest results in circulating mtDNA levels, which reduced during a temperature management protocol in patients with a target temperature of 33 °C. |
| Databáze: | OpenAIRE |
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