Emerging technologies and commercial products in exosome-based cancer diagnosis and prognosis
| Autor: | Mehdi Mohammadi, Hossein Zargartalebi, Raied Aburashed, Amir Sanati-Nezhad, Razieh Salahandish, Kar Wey Yong |
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| Rok vydání: | 2020 |
| Předmět: |
business.industry
Emerging technologies 010401 analytical chemistry Microfluidics Biomedical Engineering Biophysics Cancer Clinical settings 02 engineering and technology General Medicine Biosensing Techniques 021001 nanoscience & nanotechnology medicine.disease Exosomes Prognosis 01 natural sciences Exosome 0104 chemical sciences Risk analysis (engineering) Neoplasms Electrochemistry Medicine 0210 nano-technology business Biotechnology |
| Zdroj: | Biosensorsbioelectronics. 183 |
| ISSN: | 1873-4235 |
| Popis: | Academic and industrial groups worldwide have reported technological advances in exosome-based cancer diagnosis and prognosis. However, the potential translation of these emerging technologies for research and clinical settings remains unknown. This work overviews the role of exosomes in cancer diagnosis and prognosis, followed by a survey on emerging exosome technologies, particularly microfluidic advances for the isolation and detection of exosomes in cancer research. The advantages and drawbacks of each of the technologies used for the isolation, detection and engineering of exosomes are evaluated to address their clinical challenges for cancer diagnosis and prognosis. Furthermore, commercial platforms for exosomal detection and analysis are introduced, and their performance and impact on cancer diagnosis and prognosis are assessed. Also, the risks associated with the further development of the next generation of exosome devices are discussed. The outcome of this work could facilitate recognizing deliverable Exo-devices and technologies with unprecedented functionality and predictable manufacturability for the next-generation of cancer diagnosis and prognosis. |
| Databáze: | OpenAIRE |
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