α-[Amino(4-aminophenyl)thio]methylene-2-(trifluoromethyl)benzeneacetonitrile; Configurational Equilibria in Solution
| Autor: | Herbert H. Seltzman, Jeffrey R. Deschamps, P. Anantha Reddy, S. Wayne Mascarella, Anita H. Lewin, Larry Brieaddy, F. Ivy Carroll, Scott E. Fix, Charles J. McElhinny, Gregory H. Imler |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Aqueous solution
Trifluoromethyl Molecular Structure 010405 organic chemistry Organic Chemistry Thio 01 natural sciences Biochemistry E-Z notation Medicinal chemistry Article 0104 chemical sciences Solutions 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Drug Discovery Proton NMR Aminoacetonitrile Methylene Solubility Molecular Biology Cis–trans isomerism |
| Zdroj: | Bioorg Chem |
| Popis: | Inconsistent results have been reported for the effects of the mitogen-activating extracellular kinase (MEK) inhibitor α-[amino(4-aminophenyl)thio]methylene-2-(trifluoromethyl)benzeneacetonitrile (SL 327) on ethanol-induced conditioned place preference (EtOH-CPP). Since such inconsistencies may be due to the configurational composition of administered SL 327, the interconvertibility of the geometric isomers of this class of compounds has been investigated. This study provides conditions for determination of configurational composition of this class of compounds by HPLC and by (1)H NMR and reports details of configurational equilibria as a function of medium and time in solution along with solubility data for SL 327 in aqueous DMSO. The results suggest that the apparently inconsistent results reported for CPP-EtOH may be due to the administration of suspension vs. solutions, as well as to different configurational compositions of SL 327. |
| Databáze: | OpenAIRE |
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