Ophthalmic gels: Past, present and future
| Autor: | Ghada Zidan, Adam W.G. Alani, Ali A. Al-Kinani, Naba Elsaid, Ali Seyfoddin, Raid G. Alany |
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| Rok vydání: | 2018 |
| Předmět: |
3d printed
Materials science Biocompatibility Polymers Pharmaceutical Science 02 engineering and technology 010402 general chemistry 01 natural sciences law.invention Drug Delivery Systems Hydrophilic polymers law Humans Patient compliance Wound Healing 3D bioprinting Responsive systems 021001 nanoscience & nanotechnology 0104 chemical sciences Printing Three-Dimensional Drug delivery Self-healing hydrogels Ophthalmic Solutions 0210 nano-technology Gels Biomedical engineering |
| Zdroj: | Advanced Drug Delivery Reviews. 126:113-126 |
| ISSN: | 0169-409X |
| DOI: | 10.1016/j.addr.2017.12.017 |
| Popis: | Aqueous gels formulated using hydrophilic polymers (hydrogels) along with those based on stimuli responsive polymers (in situ gelling or gel forming systems) continue to attract increasing interest for various eye health-related applications. They allow the incorporation of a variety of ophthalmic pharmaceuticals to achieve therapeutic levels of drugs and bioactives at target ocular sites. The integration of sophisticated drug delivery technologies such as nanotechnology-based ones with intelligent and environment responsive systems can extend current treatment duration to provide more clinically relevant time courses (weeks and months instead of hours and days) which will inevitably reduce dose frequency, increase patient compliance and improve clinical outcomes. Novel applications and design of contact lenses and intracanalicular delivery devices along with the move towards integrating gels into various drug delivery devices like intraocular pumps, injections and implants has the potential to reduce comorbidities caused by glaucoma, corneal keratopathy, cataract, diabetic retinopathies and age-related macular degeneration. This review describes ophthalmic gelling systems with emphasis on mechanism of gel formation and application in ophthalmology. It provides a critical appraisal of the techniques and methods used in the characterization of ophthalmic preformed gels and in situ gelling systems along with a thorough insight into the safety and biocompatibility of these systems. Newly developed ophthalmic gels, hydrogels, preformed gels and in situ gelling systems including the latest in the area of stimuli responsive gels, molecularly imprinted gels, nanogels, 3D printed hydrogels; 3D printed devices comprising ophthalmic gels are covered. Finally, new applications of gels in the production of artificial corneas, corneal wound healing and hydrogel contact lenses are described. |
| Databáze: | OpenAIRE |
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