Intertwined reproductive endocrinology: Puberty and polycystic ovary syndrome
| Autor: | Tony M. Plant, Selma F. Witchel |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty endocrine system diseases medicine.drug_class Endocrinology Diabetes and Metabolism Reproductive Endocrinology 030209 endocrinology & metabolism Ovary Article 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Testosterone business.industry Adrenarche Hyperandrogenism nutritional and metabolic diseases medicine.disease Androgen Polycystic ovary female genital diseases and pregnancy complications 030104 developmental biology Endocrinology medicine.anatomical_structure Gonadarche business |
| Zdroj: | Curr Opin Endocr Metab Res |
| ISSN: | 2451-9650 |
| DOI: | 10.1016/j.coemr.2020.07.004 |
| Popis: | Polycystic ovary syndrome (PCOS) is a heterogeneous familial disorder often emerging during the peri-pubertal years concomitantly with the onset of gonadarche and adrenarche. Both gonadarche and PCOS reflect functional changes in the hypothalamic-pituitary-ovarian axis. During this transition, normal girls manifest features consistent with PCOS such as irregular menses, mild hyperandrogenism, and multi-follicular ovary morphology. Themes common to puberty and PCOS, neuroendocrine features, androgen exposure, and insulin sensitivity, will be considered to address the possibility that PCOS interferes with the normal pubertal transition. |
| Databáze: | OpenAIRE |
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