Hydatid Cyst Protoscolices Induce Cell Death in WEHI-164 Fibrosarcoma Cells and Inhibit the Proliferation of Baby Hamster Kidney Fibroblasts In Vitro
| Autor: | Hedayatollah Shirzad, Fatomeh Taji, Hossein Yousofi Darani, Soliman Khorami, Narges Soozangar, Mortaza Yousofi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Programmed cell death
Pathology medicine.medical_specialty Cell type Article Subject Cell growth Cell Biology medicine.disease In vitro lcsh:Infectious and parasitic diseases Andrology Infectious Diseases medicine.anatomical_structure parasitic diseases medicine Baby hamster kidney cell Parasitology lcsh:RC109-216 Fibrosarcoma Fibroblast Research Article |
| Zdroj: | Journal of Parasitology Research, Vol 2012 (2012) Journal of Parasitology Research |
| ISSN: | 2090-0023 |
| DOI: | 10.1155/2012/304183 |
| Popis: | Bothin vitroandin vivomodels have demonstrated that some parasites can interfere with tumor cell growth. The present study investigates the anticancer activity of hydatid cyst protoscolices on WEHI-164 fibrosarcoma cells and baby hamster kidney (BHK) fibroblast cellsin vitro. Those above two cell types were treated with live hydatid cyst protoscolices or left untreated for control groups. After 48 h, lactate dehydrogenase (LDH) and cell counts were assayed for both treated cells and control groups. Following treatment with hydatid cyst protoscolices, cell proliferation of both cell types was inhibited, and lysis of fibrosarcoma cells increased. Based on these results, it appears that hydatid cyst protoscolices have strong anticancer activity, and additional studies are needed to further clarify the mechanisms of this activity. |
| Databáze: | OpenAIRE |
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