Genetic diversity of HLA system in three populations from Coahuila, Mexico : Torreón, Saltillo and rural Coahuila
| Autor: | Marisela del Rocío González-Martínez, Carolina Bekker-Méndez, Federico Juárez-de la Cruz, Julio Granados, Joaquín Zúñiga, Abraham Lona-Sánchez, Michael H. Crawford, Javier Morán-Martínez, Liliana González-Medina, Esteban Arrieta-Bolaños, Néstor Escareño-Montiel, Hanna Pacheco-Ubaldo, Diana Iraíz Hernández-Zaragoza, Stephen Clayton, Yolanda Jaramillo-Rodríguez, Carmen Adalid-Sáinz, Edmond J. Yunis, Alicia Bravo-Acevedo, Héctor Delgado-Aguirre, Rodrigo Barquera, Antonio Salgado-Adame |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Rural Population
Genetic diversity Immunology Medizin Population genetics Genetic Variation General Medicine Immunogenetics Human leukocyte antigen Linkage Disequilibrium Geography Genetics Population Gene Frequency Haplotypes Evolutionary biology HLA Antigens Ethnicity Immunology and Allergy Humans Mexico Alleles |
| Popis: | We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 684 Mexicans from the state of Coahuila living in Saltillo (N = 72), Torreón (N = 396) and rural communities (N = 216), to obtain information regarding allelic and haplotypic frequencies. We find that the ten most frequent haplotypes found in the state of Coahuila include eight Native American and two European haplotypes. Admixture estimates revealed that the main genetic components in the state of Coahuila are European (49.72 ± 4.18% by ML; 37.49% of European haplotypes) and Native American (45.01 ± 2.69% by ML; 42.98% of Native American haplotypes), while African genetic component is less apparent (5.27 ± 1.88% by ML; 9.92% of African haplotypes). |
| Databáze: | OpenAIRE |
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