Immunohistochemical prognostic index for breast cancer in young women
| Autor: | R Díaz de Otazu, J Algorta, J Fariña, I Guerra, A Pelayo |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Oncology medicine.medical_specialty Pathology Multivariate analysis Adolescent Receptor ErbB-2 Mammary gland Breast Neoplasms Disease-Free Survival Pathology and Forensic Medicine Breast cancer Internal medicine Progesterone receptor Biomarkers Tumor medicine Carcinoma Humans Prospective Studies Stage (cooking) Lymph node business.industry Carcinoma Ductal Breast Original Articles Prognosis medicine.disease Survival Rate medicine.anatomical_structure Receptors Estrogen Multivariate Analysis Nottingham Prognostic Index Female Tumor Suppressor Protein p53 Receptors Progesterone business Follow-Up Studies |
| Zdroj: | Molecular Pathology. 56:323-327 |
| ISSN: | 1366-8714 |
| DOI: | 10.1136/mp.56.6.323 |
| Popis: | Aims Women under 35 years of age comprise a small proportion of patients with breast cancer, but determining their prognosis can be difficult. This prospective, multivariate study looked at several factors with the aim of obtaining a useful index to evaluate the prognosis of these women. Methods In total, 108 patients below 35 years of age affected by invasive ductal carcinoma without distant metastasis were studied. The mean duration of the follow up period was six years. Histopathological (tumour size, histological grade, and lymph node stage) and immunohistochemical (c-erbB-2, p53, oestrogen receptor, and progesterone receptor) factors were measured in all patients, and the Nottingham prognostic index (NPI) was then calculated. An immunohistochemical prognostic index (IHPI) was created using the arithmetic sum of the four individual immunohistochemical factors. Results In univariate assessment of survival, all the studied factors yielded a significant association with either overall survival or disease free survival, except for c-erbB-2 and p53 with disease free survival. In univariate calculation of risk, all the factors gave significant results; however, in multivariate analysis only tumour size, histological grade, and progesterone receptor were significant. Both NPI and IHPI correlated significantly with prognosis. In multivariate regression analysis, IHPI correlated with tumour size and there was a significant interaction between both variables. Conclusion IHPI is very useful in determining the prognosis of tumours 2, although it has no use in tumours > 5 cm. |
| Databáze: | OpenAIRE |
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