Association of cognitive impairment and breast cancer survivorship on quality of life in younger breast cancer survivors
| Autor: | Adele Crouch, David Cella, Frederick W. Unverzagt, Susan Storey, Victoria L. Champion, Patrick O. Monahan, Diane Von Ah, Timothy E. Stump, Andrea A. Cohee |
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| Rok vydání: | 2021 |
| Předmět: |
Breast Neoplasms
03 medical and health sciences 0302 clinical medicine Breast cancer Cancer Survivors Quality of life Humans Medicine Verbal fluency test Cognitive Dysfunction 030212 general & internal medicine Effects of sleep deprivation on cognitive performance Neuropsychological assessment Fatigue Depression (differential diagnoses) medicine.diagnostic_test Oncology (nursing) business.industry Cognition medicine.disease Oncology 030220 oncology & carcinogenesis Psychological well-being Quality of Life Female business Clinical psychology |
| Zdroj: | Journal of Cancer Survivorship. 16:812-822 |
| ISSN: | 1932-2267 1932-2259 |
| DOI: | 10.1007/s11764-021-01075-x |
| Popis: | Purpose Younger breast cancer survivors (BCS) often report cognitive impairment and poor quality of life (QoL), which could be interrelated. The purpose of this study was to examine the association of cognitive impairment and breast cancer status (BCS versus healthy control (HC)), with QoL, which included psychological (depressive symptoms, well-being, perceived stress, and personal growth) and physical well-being (physical functioning and fatigue). Methods Four hundred ninety-eight BCS (≤45 years at diagnosis) who were 3 to 8 years post-chemotherapy treatment and 394 HC completed subjective questionnaires and a one-time neuropsychological assessment, including tests of attention, memory, processing speed, and verbal fluency. For each test, cognitive impairment was defined as scoring 1.5 and 2.0 standard deviations below the mean of the HC group. Separate linear regression models for each outcome were ran controlling for known covariates. Results BCS reported significantly more memory problems than HC (p < 0.0001), with up to 23% having significant impairment. Cognitive performance did not differ significantly between BCS and HCs. BCS vs. HCs had greater depression and fatigue, yet more personal growth. Objective and subjective cognitive impairment were significantly related to greater depressive symptoms and perceived stress and lower well-being and physical functioning; whereas, objective impairment was related to less personal growth and subjective impairment was related to greater fatigue. Conclusions Younger BCS report significant cognitive impairment years after treatment which may relate to greater decrements in QoL. Implications to Cancer Survivors Assessment and interventions to address cognitive concerns may also influence QoL outcomes in younger BCS. |
| Databáze: | OpenAIRE |
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