Antiglycan antibodies as serological markers in the differential diagnosis of inflammatory bowel disease
| Autor: | C Sguazzini, Rinaldo Pellicano, Roberto Pagni, Giulio Mengozzi, D Simondi, Mario Rizzetto, Roberta Patrizia Ghignone, Sharmila Fagoonee, Silvia Betteto, R. Bonardi, Marco Astegiano |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Saccharomyces cerevisiae Disease Inflammatory bowel disease Gastroenterology Antibodies Serology Diagnosis Differential Immunoenzyme Techniques Polysaccharides Internal medicine medicine Anti-Saccharomyces cerevisiae antibodies Crohn's disease Ulcerative colitis Humans Immunology and Allergy Prospective Studies Prospective cohort study Antibodies Fungal Aged Aged 80 and over business.industry Middle Aged Inflammatory Bowel Diseases medicine.disease ROC Curve Female Differential diagnosis business Biomarkers Follow-Up Studies Cohort study |
| Zdroj: | Inflammatory bowel diseases 14 (2008): 645–651. doi:10.1002/ibd.20368 info:cnr-pdr/source/autori:Simondi, Daniele; Mengozzi, Giulio; Betteto, Silvia; Bonardi, Renato; Ghignone, Roberta Patrizia; Fagoonee, Sharmila; Pellicano, Rinaldo; Sguazzini, Carlo; Pagni, Roberto; Rizzetto, Mario; Astegiano, Marco/titolo:Antiglycan antibodies as serological markers in the differential diagnosis of inflammatory bowel disease/doi:10.1002%2Fibd.20368/rivista:Inflammatory bowel diseases/anno:2008/pagina_da:645/pagina_a:651/intervallo_pagine:645–651/volume:14 |
| DOI: | 10.1002/ibd.20368 |
| Popis: | Background: The objective of the study was to evaluate the diagnostic accuracy of recently developed antiglycan serological tests in clinical practice for the diagnosis of Crohn's disease. Methods: This study was a cohort analysis of both clinical and biochemical parameters of patients with diagnosed inflammatory bowel disease compared with those in a control population. Antiglycan antibodies were determined using commercially available enzyme immunoassays. The setting was the outpatient unit of the gastroenterology department of a large, tertiary-care referral academic hospital. Participants were 214 consecutive patients, enrolled over a 5-month period, including 116 with Crohn's disease and 53 with ulcerative colitis, as well as 45 with other gastrointestinal diseases and 51 healthy controls. Results: Anti–Saccharomyces cerevisiae antibodies showed the best performance (54% sensitivity and 88%–95% specificity for Crohn's disease). Among patients with negative anti-Saccharomyces antibodies, 19 (34%) had high titers of at least another tested antiglycan antibody. Anti-Saccharomyces and anti-laminaribioside antibodies were associated with disease involving the small bowel and with penetrating or stricturing phenotype. Anti-laminaribioside was significantly higher in patients with a familial history of inflammatory bowel disease. Conclusions: The new proposed serological markers are significantly associated with Crohn's disease, with low sensitivity but good specificity. About one third of anti-Saccharomyces-negative patients may be positive for at least 1 of those markers. Antiglycan antibodies appear to be associated with characteristic localization and phenotype of the disease. (Inflamm Bowel Dis 2008) |
| Databáze: | OpenAIRE |
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