Nasal administration of naloxone for detection of opiate dependence
| Autor: | N. Loimer, Peter Hofmann, Haroon Rashid Chaudhry |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Pharmacology Route of administration Naloxone Pupillary response Humans Medicine Administration Intranasal Biological Psychiatry Opiate dependence Neurologic Examination business.industry Narcotic antagonist Middle Aged Opioid-Related Disorders Substance Withdrawal Syndrome Hospitalization Substance Abuse Detection Psychiatry and Mental health Blood pressure Prisons Anesthesia Nasal administration Opiate business medicine.drug |
| Zdroj: | Journal of Psychiatric Research. 26:39-43 |
| ISSN: | 0022-3956 |
| DOI: | 10.1016/0022-3956(92)90014-f |
| Popis: | In clinical trials, nasally applied naloxone was used to identify opiate dependence in humans for the first time. Withdrawal distress was recorded, and pupillary response, pulse rate and blood pressure measured. A significant increase in withdrawal distress and pupillary dilation was observed after nasal administration of 1mg (1mg/400 microliters) naloxone in all subjects who also showed opiate-positive urine samples. In control subjects, no reaction to naloxone was observed. It may be concluded that the nasal route for naloxone administration is as effective as the parenteral route. This test is sensitive enough to identify the physically-dependent opiate user and might have a role in emergency medicine and withdrawal treatment. |
| Databáze: | OpenAIRE |
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