Effect of dual trigger on reproductive outcome in low responders: a systematic PRISMA review and meta-analysis
| Autor: | Ulla Breth Knudsen, Amalie Sloth, Karoline Gundersen Sarmon, Maria Kjølhede |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Pregnancy Rate reproductive outcome Endocrinology Diabetes and Metabolism Fertilization in Vitro Chorionic Gonadotropin Dual trigger law.invention Human chorionic gonadotropin Gonadotropin-Releasing Hormone Endocrinology Ovulation Induction systematic review Randomized controlled trial Pregnancy law Internal medicine medicine Humans Embryo Implantation business.industry Obstetrics and Gynecology Low responder Pregnancy rate Systematic review Pooled analysis IVF Meta-analysis poor ovarian responders Female Live birth business diminished ovarian reserve |
| Zdroj: | Sloth, A, Kjølhede, M, Sarmon, K G & Knudsen, U B 2022, ' Effect of dual trigger on reproductive outcome in low responders : a systematic PRISMA review and meta-analysis ', Gynecological Endocrinology, vol. 38, no. 3, pp. 213-221 . https://doi.org/10.1080/09513590.2021.2000962 |
| ISSN: | 1473-0766 0951-3590 |
| DOI: | 10.1080/09513590.2021.2000962 |
| Popis: | Objective: Poor ovarian responders (PORs) pose a great challenge for fertility clinics worldwide. The aim of this study was to examine whether ‘dual trigger’ consisting of human chorionic gonadotropin (hCG) plus gonadotropin-releasing hormone agonist (GnRHa) is beneficial or not regarding implantation rate, pregnancy rate, and live birth rate for POR. Methods: This systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement. Risk of bias was evaluated by the Newcastle–Ottawa scale or version 2 (NOS) of the Cochrane risk-of-bias tool for randomized trials (ROB2) independently by two authors. Furthermore, RevMan version 5.4 was used to analyze the extracted data and to create an inverse-weighted summary-odds ratio (OR). Results: A total of 1390 studies were screened. Seven studies containing a total of 2474 POR were included. The pooled meta-analysis revealed a 1.62-fold increase in clinical pregnancy rate (OR = 1.62 [1.00, 2.62], p =.05) and a 2.65-fold increase in live birth rate (OR = 2.65 [1.66, 4.24], p |
| Databáze: | OpenAIRE |
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