Relationship between the airway wall area and asthma control score in moderate persistent asthma

Autor: Pierre-Yves Brillet, Yahya Ould-Hmeidi, Pascal Chanez, Catalin Fetita, Lukasz Adamek, Gaëlle Nachbaur, Margarete Ortner, Catherine Beigelman-Aubry, Philippe Grenier
Přispěvatelé: Réponses Cellulaires et Fonctionnelles à l'Hypoxie (LRPH), Université Paris 13 (UP13)-Université Sorbonne Paris Cité (USPC)-UFR SMBH, Université Pierre et Marie Curie - Paris 6 (UPMC), Département Advanced Research And Techniques For Multidimensional Imaging Systems (ARTEMIS), Institut Mines-Télécom [Paris] (IMT)-Télécom SudParis (TSP), Mathématiques Appliquées Paris 5 (MAP5 - UMR 8145), Université Paris Descartes - Paris 5 (UPD5)-Institut National des Sciences Mathématiques et de leurs Interactions (INSMI)-Centre National de la Recherche Scientifique (CNRS), CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), GlaxoSmithKline (GSK), GSK, Unité des Rickettsies et pathogènes émergents (URPE), Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, INSB-INSB-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, INSB-INSB-Centre National de la Recherche Scientifique (CNRS), Département Advanced Research And Techniques For Multidimensional Imaging Systems (TSP - ARTEMIS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS), Réponses Cellulaires et Fonctionnelles à l'Hypoxie ( LRPH ), Université Paris 13 ( UP13 ) -Université Sorbonne Paris Cité ( USPC ) -UFR SMBH, Université Pierre et Marie Curie - Paris 6 ( UPMC ), Département Advanced Research And Techniques For Multidimensional Imaging Systems ( ARTEMIS ), Institut Mines-Télécom [Paris]-Télécom SudParis ( TSP ), Mathématiques Appliquées à Paris 5 ( MAP5 - UMR 8145 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National des Sciences Mathématiques et de leurs Interactions-Centre National de la Recherche Scientifique ( CNRS ), CHU Pitié-Salpêtrière [APHP], GlaxoSmithKline ( GSK ), Unité des Rickettsies et pathogènes émergents ( URPE ), Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes ( URMITE ), Institut de Recherche pour le Développement ( IRD ) -Aix Marseille Université ( AMU ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -IFR48, INSB-INSB-Centre National de la Recherche Scientifique ( CNRS ) -Institut de Recherche pour le Développement ( IRD ) -Aix Marseille Université ( AMU ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -IFR48, INSB-INSB-Centre National de la Recherche Scientifique ( CNRS )
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Male
MESH: Asthma
Body Surface Area
[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging
[ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing
0302 clinical medicine
MESH : Cross-Sectional Studies
MESH: Body Surface Area
[INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing
Asthma control
Forced Expiratory Volume
MESH : Tomography
X-Ray Computed
Medicine
MESH : Female
030212 general & internal medicine
MESH: Bronchography
MESH : Bronchography
Lung
[ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging
Body surface area
MESH: Middle Aged
MESH: Bronchi
General Medicine
MESH : Adult
Bronchography
Middle Aged
respiratory system
MESH : Bronchi
medicine.anatomical_structure
Airway wall
MESH : Airway Remodeling
Airway Remodeling
MESH : Forced Expiratory Volume
Female
Radiology
MESH : Software
MESH: Tomography
X-Ray Computed
[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing
MESH : Body Surface Area
Adult
medicine.medical_specialty
[ INFO.INFO-TS ] Computer Science [cs]/Signal and Image Processing
MESH : Lung
MESH : Male
Bronchi
MESH: Forced Expiratory Volume
MESH : Asthma
03 medical and health sciences
MESH: Software
MESH: Cross-Sectional Studies
Humans
Radiology
Nuclear Medicine and imaging
MESH : Middle Aged
MESH: Lung
Asthma
MESH: Humans
business.industry
MESH : Humans
MESH: Adult
medicine.disease
MESH: Male
respiratory tract diseases
MESH: Airway Remodeling
Cross-Sectional Studies
030228 respiratory system
business
Airway
Tomography
X-Ray Computed
MESH: Female
Asthma Control Test
Software
Zdroj: European Radiology
European Radiology, Springer Verlag, 2013, 23 (6), pp.1594-602. ⟨10.1007/s00330-012-2743-4⟩
European Radiology, 2013, 23 (6), pp.1594-602. ⟨10.1007/s00330-012-2743-4⟩
European Radiology, Springer Verlag, 2013, 23 (6), pp.1594-602. 〈10.1007/s00330-012-2743-4〉
ISSN: 0938-7994
1432-1084
DOI: 10.1007/s00330-012-2743-4⟩
Popis: International audience; OBJECTIVES: To assess the association between airway wall area and clinical asthma control, assessed by the Asthma Control Test (ACT). METHODS: This cross-sectional study evaluated 96 adults for asthma control ["at least well controlled" (ACT ≥ 20; n = 52) or "not well controlled" (ACT < 20; n = 44) and airway dimensions: luminal area (LA), wall area (WA) and WA%], obtained using automated dedicated software measurements from volumetric CT images. Results were analysed for segmental bronchi, subsegmental bronchi in the right upper lobe and basilar segments, both uncorrected and corrected for body surface area (BSA). RESULTS: For all bronchi corrected for BSA, there was no correlation between airway wall area and ACT score. There was a weak but statistically significant correlation between uncorrected WA and ACT score (r = -0.203; P = 0.047); WA values were numerically higher in the "not well-controlled" versus the "at least well-controlled asthma" subgroups. For sub-segmental bronchi, there was a correlation between the ACT score and both WA/BSA (r = -0.204; P = 0.047) and WA (r = -0.249; P = 0.014), and for upper lobe bronchi, between the ACT score and WA (r = -0.207; P = 0.044). CONCLUSION: We demonstrated a correlation between subsegmental bronchial airway measurements and clinical control of asthma; this is probably a reflection of airway remodelling and structural changes in chronic poorly controlled asthma. KEY POINTS : * Volumetric computed tomography offers new insights into bronchial morphology. * The relationship between current asthma control and airway wall abnormalities is assessed. * Some relationships between airway wall area and clinical control were demonstrated. * We observed less shape variation of bronchi in "not well-controlled" asthma patients.
Databáze: OpenAIRE
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