Extracellular miRNAs for the Management of Barrett’s Esophagus and Esophageal Adenocarcinoma: A Systematic Review
| Autor: | Takahiro Ochiya, Kazumi Inokuchi, Juntaro Matsuzaki |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty lcsh:Medicine Disease Review 03 medical and health sciences 0302 clinical medicine Internal medicine microRNA medicine Extracellular esophageal cancer Esophagus miRNA business.industry lcsh:R General Medicine GERD Esophageal cancer medicine.disease medicine.anatomical_structure 030220 oncology & carcinogenesis Barrett's esophagus Biomarker (medicine) biomarker 030211 gastroenterology & hepatology business |
| Zdroj: | Journal of Clinical Medicine Journal of Clinical Medicine, Vol 10, Iss 117, p 117 (2021) |
| ISSN: | 2077-0383 |
| Popis: | Esophageal adenocarcinoma (EAC), the major histologic type of esophageal cancer (EC) in Western countries, is a disease with a poor prognosis, primarily due to usual diagnosis at an advanced stage. The prevalence of EAC has increased in recent years, both in Western countries and in Asia. Barrett’s esophagus (BE) is a precursor lesion of EAC. Therefore, early detection and proper management of BE and EAC is important to improve prognosis. Here, we systematically summarize current knowledge about the potential utility of extracellular microRNAs (miRNAs), which are thought to be non-invasive biomarkers for many diseases, for these purposes. A search of the PubMed and Embase databases identified 22 papers about extracellular miRNAs that have potential utility for management of EAC. Among them, 19 were EAC-related and ten were BE-related; some of these dealt with both conditions. The articles included studies reporting diagnosis, prognosis, and treatment responses. Multiple papers report dysregulation of miR-194-5p in BE and miR-21-5p, -25-3p, and -93-5p in EAC. Although it will take time to utilize these miRNAs in clinical practice, they are likely to be useful non-invasive markers in the future. |
| Databáze: | OpenAIRE |
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