Measuring the foveal avascular zone in diabetes: A study using optical coherence tomography angiography
| Autor: | Rachel Kir, Graeme J. Kennedy, Jasmine Hui, Ross T. Aitchison, Uma Shahani, Xinhua Shu, David Mansfield |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Fovea Centralis Capillary plexus genetic structures Endocrinology Diabetes and Metabolism Hba1c level Ophthalmology Diabetes mellitus Internal Medicine Diabetes Mellitus Medicine Humans Fluorescein Angiography Ocular disease Microvascular complication business.industry Retinal Vessels General Medicine Optical coherence tomography angiography Foveal avascular zone medicine.disease eye diseases Multiple linear regression analysis sense organs business Tomography Optical Coherence |
| Zdroj: | Journal of diabetes investigation. 13(4) |
| ISSN: | 2040-1124 |
| Popis: | Introduction Diabetes is a global issue that currently affects 425 million people worldwide. One observable microvascular complication of this condition is a change in the foveal avascular zone (FAZ). In this study, we used optical coherence tomography angiography (OCT-A) to investigate the effect of diabetes on the FAZ. Materials and methods Eleven diabetic and eleven non-diabetic participants took part in this study. Participants in both groups were matched for age (p = 0.217) and sex (p = 0.338), and had no history of ocular disease. Macular OCT-A scans of participants' right and left eyes were taken. Glycosylated haemoglobin (HbA1c ) and blood glucose levels were also measured. The FAZ area was manually segmented at the levels of the superficial capillary plexus (FAZSCP ) and deep capillary plexus (FAZDCP ). Results There was a strong relationship between the FAZ area of participants' right and left eyes (p ≤ 0.001) in both diabetic and non-diabetic groups. In the diabetic group, the FAZSCP (p = 0.047) and FAZDCP (p = 0.011) areas was significantly larger than in the non-diabetic group. Moreover, multiple linear regression analysis predicted a 0.07-mm2 increase in diabetic individuals' FAZSCP and FAZDCP areas for every 1% increase in their HbA1c level. Conclusions Our findings indicate that there is enlargement of the FAZ in diabetic individuals compared with non-diabetic individuals. In the diabetic group, this enlargement appears to be correlated with HbA1c level. OCT-A imaging could, therefore, be a useful tool to monitor the FAZ and identify potential early microvasculopathy in diabetes. |
| Databáze: | OpenAIRE |
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