Bronchopulmonary dysplasia as a risk factor for asthma in school children and adolescents: A systematic review
| Autor: | S. Pérez Tarazona, E. Bartoll Alguacil, P. Solano Galán, J. Alfonso Diego |
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| Rok vydání: | 2018 |
| Předmět: |
Pulmonary and Respiratory Medicine
Pediatrics medicine.medical_specialty Adolescent Immunology Population MEDLINE behavioral disciplines and activities Asthma Bronchopulmonary dysplasia Outcome Prematurity Very low birth weight 03 medical and health sciences 0302 clinical medicine Risk Factors 030225 pediatrics Statistical significance mental disorders Immunology and Allergy Medicine Humans Risk factor Child Asthma Bronchopulmonary Dysplasia business.industry Confounding General Medicine medicine.disease 030228 respiratory system Bronchopulmonary dysplasia Homogeneous Physical therapy business Complication |
| Zdroj: | ALLERGOLOGIA ET IMMUNOPATHOLOGIA r-FISABIO: Repositorio Institucional de Producción Científica Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
| ISSN: | 0301-0546 |
| Popis: | Background Bronchopulmonary dysplasia (BPD) is a chronic lung disease that mainly affects extremely pre-term infants, and remains the most common complication of prematurity. Several studies have shown that prematurity predisposes to the development of asthma in school children and adolescents. Nevertheless, it is not clear to what extent a history of BPD involves an additional risk. Methods A systematic review of studies assessing the association between BPD and asthma in school-children and adolescents was made. A literature search was carried out in the MEDLINE and EMBASE databases to retrieve articles published between 1 January 2000 and 31 August 2016. Results A total of 17 studies comprising 7433 patients were included in the review. There was considerable heterogeneity in the definitions of BPD and asthma among studies. Overall, the prevalence of asthma was higher in children and adolescents with a history of prematurity and BPD compared with those who did not develop BPD. However, in only one of the studies did this difference reach statistical significance. The main limitation of this review was potential bias due to the lack of adjustment for confounding factors between exposure (BPD) and outcome (asthma) in most of the studies. Conclusion Based on the studies reviewed, it cannot be argued that BPD, as an independent factor of prematurity, increases the risk of asthma defined by clinical parameters in school-children and adolescents. Further studies of greater methodological quality and homogeneous diagnostic criteria of BPD and asthma are needed for improved assessment of this association. |
| Databáze: | OpenAIRE |
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