A C-Terminal Fragment of Agouti-Related Protein Increases Feeding and Antagonizes the Effect of Alpha-Melanocyte Stimulating Hormonein Vivo
| Autor: | Sarah Stanley, Caroline J. Small, M. A. Ghatei, D. Sunter, David G.A. Morgan, Anthony P. Goldstone, S. H. Russell, David M. Smith, M. Rossi, K. Yagaloff, C. M. B. Edwards, Min Seon Kim, Stephen R. Bloom, S. Abusnana |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
Agonist medicine.medical_specialty medicine.drug_class Biology Eating chemistry.chemical_compound Endocrinology Central melanocortin system Internal medicine medicine Animals Agouti-Related Protein Rats Wistar Receptor Injections Intraventricular Dose-Response Relationship Drug digestive oral and skin physiology Antagonist Proteins Peptide Fragments alpha-Melanocyte-stimulating hormone Rats medicine.anatomical_structure Receptors Corticotropin chemistry alpha-MSH Hypothalamus Agouti Signaling Protein Intercellular Signaling Peptides and Proteins Melanocortin Agouti-related peptide hormones hormone substitutes and hormone antagonists Receptor Melanocortin Type 3 |
| Zdroj: | Endocrinology. 139:4428-4431 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo.139.10.6332 |
| Popis: | Agouti-related protein (Agrp) is present in rat and human hypothalamus and is structurally related to agouti protein. Overexpression of either of these proteins results in obesity. However the effect of exogenous Agrp and its in vivo interaction with alpha-melanocyte stimulating hormone (alphaMSH), the likely endogenous melanocortin 3 and 4 receptor (MC3-R and MC4-R) agonist, have not been demonstrated. We report that 1 nmol of Agrp(83-132), a C-terminal fragment of Agrp, when administered intracerebroventricularly (ICV) into rats, increased food intake over a 24-h period (23.0+/-1.4 g saline vs 32.9+/-2.3 g Agrp, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|