Uterine peristalsis and fertility: current knowledge and future perspectives: a review and meta-analysis
| Autor: | W.G. Methorst, Massimo Mischi, Benedictus C. Schoot, N.P. Kuijsters, Chiara Rabotti, Madeleine Susanne Quirine Kortenhorst |
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| Přispěvatelé: | Signal Processing Systems, Biomedical Diagnostics Lab |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Peristalsis/drug effects media_common.quotation_subject Uterus Fertility Uterus/anatomy & histology Bioinformatics 03 medical and health sciences 0302 clinical medicine medicine Humans Progesterone Progestins/therapeutic use media_common Gynecology Pregnancy 030219 obstetrics & reproductive medicine Intrauterine insemination business.industry assisted reproduction Obstetrics and Gynecology Uterine peristalsis medicine.disease Embryo Transfer Progesterone/therapeutic use Embryo transfer Quality of evidence meta-analysis 030104 developmental biology medicine.anatomical_structure Reproductive Medicine IVF Meta-analysis Peristalsis uterine contractions uterine peristalsis Female Progestins business infertility Developmental Biology |
| Zdroj: | Reproductive BioMedicine Online, 35(1), 50-71. Elsevier |
| ISSN: | 1472-6483 |
| Popis: | Although uterine contractions in the non-pregnant uterus have been studied extensively, the knowledge gained has not been used in general fertility treatment work-up. In this review paper, we provide an overview of the current knowledge on uterine peristalsis (UP), based on the available literature. This literature shows that UP influences pregnancy chances in both natural and artificial cycles. Although the physiological background of these contractions is not completely clear, we know that several factors can be of influence, like uterine pathologies and hormones. Several options to alter pregnancy outcome by interfering with uterine contractions have been studied. Our meta-analysis on therapeutic options shows positive results of progesterone at time of embryo transfer in IVF cycles or prostaglandins at time of intrauterine insemination, although the quality of evidence is low. These therapies are probably most beneficial in selected groups of patients with abnormal contraction patterns. The introduction of an objective and user-friendly UP measuring tool suitable for use in daily practice would make it possible to identify and monitor these patients. We suggest that future research should focus on the physiology of initiation of UP and on the development of an effective standard measuring tool. |
| Databáze: | OpenAIRE |
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