Reevaluation of the evolutionary events within recA/RAD51 phylogeny

Autor: Andriy Anishkin, Hong Ma, Damian B. van Rossum, Yoojin Hong, Zhenhai Zhang, Jagadish Babu, Randen L. Patterson, Loukia Hadjiyianni, George K. Todd, Sree V. Chintapalli, Casey A. Boosalis, Xiaofan Zhou, Gaurav Bhardwaj
Rok vydání: 2013
Předmět:
Zdroj: BMC Genomics
Chintapalli, Sree V; Bhardwaj, Gaurav; Babu, Jagadish; Hadjiyianni, Loukia; Hong, Yoojin; Todd, George K; et al.(2013). Reevaluation of the evolutionary events within recA/RAD51 phylogeny. BMC Genomics, 14(1), 240. doi: http://dx.doi.org/10.1186/1471-2164-14-240. Retrieved from: http://www.escholarship.org/uc/item/5w92m2xt
ISSN: 1471-2164
DOI: 10.1186/1471-2164-14-240
Popis: Background The recA/RAD51 gene family encodes a diverse set of recombinase proteins that affect homologous recombination, DNA-repair, and genome stability. The recA gene family is expressed across all three domains of life - Eubacteria, Archaea, and Eukaryotes - and even in some viruses. To date, efforts to resolve the deep evolutionary origins of this ancient protein family have been hindered by the high sequence divergence between paralogous groups (i.e. ~30% average pairwise identity). Results Through large taxon sampling and the use of a phylogenetic algorithm designed for inferring evolutionary events in highly divergent paralogs, we obtained a robust, parsimonious and more refined phylogenetic history of the recA/RAD51 superfamily. Conclusions In summary, our model for the evolution of recA/RAD51 family provides a better understanding of the ancient origin of recA proteins and the multiple events that lead to the diversification of recA homologs in eukaryotes, including the discovery of additional RAD51 sub-families.
Databáze: OpenAIRE
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