Antenatal oligohydramnios of renal origin: long-term outcome
| Autor: | Markus J. Kemper, Thomas J. Neuhaus, Ilka Klaassen, Dirk E. Mueller-Wiefel |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Time Factors Adolescent medicine.medical_treatment Renal function Oligohydramnios Pregnancy Prenatal Diagnosis medicine Humans Intensive care medicine Child Dialysis Kidney transplantation Transplantation Kidney business.industry Incidence Infant Newborn Infant medicine.disease Prognosis Survival Rate medicine.anatomical_structure Nephrology Child Preschool Female Kidney Diseases Hemodialysis business Kidney disease Follow-Up Studies |
| Popis: | Background. Prognosis of fetuses with renal oligohydramnios (ROH) is often still regarded as poor. Neonatal complications and the long-term follow-up of fetuses with ROH in two pediatric centres are described. Method. 23 fetuses (16 males, 7 females) were included as patients. Primary diseases included congenital anomalies of the kidney and urinary tract (n ¼ 16), autosomal recessive polycystic kidney disease (n ¼ 4) and renal tubular dysgenesis (n ¼ 3). The analysis includes retrospective chart review. Results. Seven children died (30%), the majority (n ¼ 4, 17%) within the neonatal period due to pulmonary hypoplasia and renal insufficiency. Fourteen patients (61%) required postnatal mechanical ventilation for a median of 4 (range 1–60) days; 11 infants had an associated pneumothorax. All 16 surviving children have chronic kidney disease (CKD) at a current median age of 5.7 years (range 0.5–14.5), managed conservatively in eight patients [median glomerular filtration rate 51 (range 20–78) ml/min/1.73 m 2 ]. Eight patients reached end-stage renal disease at a median age of 0.3 years (range 2 days to 8.3 years), including one patient with pre-emptive kidney transplantation. Five of the patients requiring dialysis underwent successful renal transplantation at a median age of 3.5 years (range 2.5–4). Growth was impaired in seven children requiring growth hormone treatment. Cognitive and motor development was normal in 12 (75%) of the 16 patients and showed a delay in four children, including two with associated syndromal features. Conclusion. ROH is not always associated with a poor prognosis and long-term outcome in survivors is encouraging. The high incidence of neonatal complications and long-term morbidity due to CKD requires a multidisciplinary management of these children. |
| Databáze: | OpenAIRE |
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