High dose propofol enhances red cell antioxidant capacity during CPB in humans
| Autor: | Jianhang Sun, David V. Godin, Maureen E. Garnett, A. Karim Qayumi, John Dolman, David M. Ansley, W. Anton Visser |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Erythrocytes Antioxidant medicine.medical_treatment Antioxidants law.invention Sufentanil Desflurane law Malondialdehyde medicine Cardiopulmonary bypass Humans Propofol Aged Cardiopulmonary Bypass Red Cell business.industry Farmaca as effector in the control of (subsystems in) anesthesia Hemodynamics General Medicine Middle Aged Red blood cell Anesthesiology and Pain Medicine medicine.anatomical_structure Farmaca als middel voor het sturen van (subsystemen in de) anesthesie Isoflurane Anesthesia Female Lipid Peroxidation business Anesthetics Intravenous medicine.drug |
| Zdroj: | Canadian Journal of Anaesthesia, 46, pp. 641-648 Canadian Journal of Anaesthesia, 46, 641-648 |
| ISSN: | 0832-610X |
| Popis: | To compare low vs. high dose propofol and isoflurane on red cell RBC antioxidant capacity in patients during aortocoronary bypass surgery (ACBP).Twenty-one patients, for ACBP, were anesthetized with sufentanil 0.5-10 microg x kg(-1) and isoflurane 0-2%; ISO = control; n = 7), or sufentanil 0.3 microg x kg(-1), propofol 1-2.5 mg x kg(-1) bolus then 100 microg x kg(-1) min(-1) before, and 50 microg x kg(-1) x min(-1) during CPB (LO; n = 7), or sufentanil 0.3 microg x kg(-1), propofol 2-2.5 mg x kg(-1) bolus then 200 microg x kg(-1) x min(-1) (HI; n = 7). Venous blood was drawn pre- and post-induction, after 30 min CPB, 5, 10, and 30 min of reperfusion, and 120 min post-CPB to measure red cell antioxidant capacity (malondialdehyde (MDA) production in response to oxidative challenge with t-butyl hydrogen peroxide) and plasma propofol concentration. Pre- induction blood samples were analyzed for antioxidant effects of nitrates on red cells. The tBHP concentration response curves for RBC MDA in ISO, LO and HI were determined.Preoperative nitrate therapy did not effect RBC MDA production. Perioperative RBC MDA production was similar in ISO and LO groups. Sustained intraoperative decrease in RBC MDA was seen with propofol 8.0+/-2.4 - 11.8+/-4.5 microg x ml(-1) in HI (P0.05-0.0001). MDA production vs. log plasma propofol concentration was linear in HI dose.During CPB, RBC antioxidant capacity is enhanced and maintained with HI dose propofol. Propofol, at this dose, may prove useful in protecting against cardiopulmonary ischemia-reperfusion injury associated with ACBP. |
| Databáze: | OpenAIRE |
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