Evidence for Sympathetic, Purinergic Transmission in the Iris Dilator Muscle of the Rabbit
| Autor: | Ikunobu Muramatsu, Yasuo Oda, Shigeru Kigoshi |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Guanethidine
Male medicine.medical_specialty Iris Adrenergic Stimulation Suramin Tetrodotoxin In Vitro Techniques Biology Adenosine Triphosphate Internal medicine medicine Prazosin Animals Neuropeptide Y Adrenergic alpha-Antagonists Pharmacology Purinergic receptor Receptors Purinergic Thionucleotides Electric Stimulation Iris dilator muscle Endocrinology Dilator Female Rabbits medicine.symptom Muscle Contraction Muscle contraction medicine.drug |
| Zdroj: | Japanese Journal of Pharmacology. 66:191-194 |
| ISSN: | 0021-5198 |
| DOI: | 10.1254/jjp.66.191 |
| Popis: | Electrical transmural stimulation of isolated iris dilator muscle of the rabbit produced a transient contraction that consisted of adrenergic and nonadrenergic components. In contrast to the adrenergic component, the nonadrenergic component was resistant to prazosin and other adrenoceptor antagonists. However, both components were completely blocked by guanethidine or tetrodotoxin. Among some tested compounds including neuropeptide Y, both ATP and 2-methylthio ATP produced a transient contraction in the dilator muscle and the sustained treatment with each markedly attenuated the nonadrenergic responses to electrical stimulation and to ATP. Suramin had no effect on and alpha,beta-methylene ATP potentiated the responses to electrical stimulation and to ATP. These results suggest that the nonadrenergic contraction induced by electrical transmural stimulation is a sympathetic purinergic response that may be mediated through unique purinoceptors. |
| Databáze: | OpenAIRE |
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