Distinct phenotypes in mixed connective tissue disease: subgroups and survival
| Autor: | Agota Hajas, Margit Zeher, Britt Nakken, Judit Végh, Istvan Csipo, László Kardos, Balazs Dezso, Eva Zold, Peter Szodoray, Gyula Szegedi, Edit Bodolay, Györgyike Soós |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Time Factors Hypertension Pulmonary Disease cluster Gastroenterology Mixed connective tissue disease Rheumatology Internal medicine Pulmonary fibrosis Prevalence medicine Cluster Analysis Humans Familial Primary Pulmonary Hypertension Longitudinal Studies Survival analysis Myositis Aged Autoantibodies Mixed Connective Tissue Disease Livedo reticularis Analysis of Variance Hungary Chi-Square Distribution business.industry Arthritis Incidence Interstitial lung disease Raynaud Disease Middle Aged Prognosis medicine.disease Survival Analysis Venous thrombosis Phenotype Disease Progression Female medicine.symptom Lung Diseases Interstitial business Biomarkers |
| Zdroj: | Lupus. 21:1412-1422 |
| ISSN: | 1477-0962 0961-2033 |
| Popis: | The aim of the present study was to assess the autoantibody profile, dominant clinical symptoms and cluster characteristics of different Mixed connective tissue disease (MCTD phenotypes. Two-hundred-and-one patients with MCTD were followed-up longitudinally. Five clinical parameters, Raynaud’s phenomenon, pulmonary artery hypertension (PAH), myositis, interstitial lung disease (ILD), erosive arthritis and five auto-antibodies besides anti-U1RNP, antiendothelial cell antibodies (AECA), anti-CCP, anti-cardiolipin (anti-CL), anti-SSA/SSB and IgM rheumatoid factor (RF) were selected for cluster analysis. The mean age of patients was 52.9 ± 12.4 years and the mean follow-up of the disease was 12.5 ± 7.2 years. Patients were classified into three cluster groups. Cluster 1 with 77 patients, cluster 2 with 79 patients and cluster 3 with 45 patients. In cluster 1 the prevalence of PAH (55.8%; p |
| Databáze: | OpenAIRE |
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