Isolation and synthesis of a novel immunosuppressive 17α-substituted dammarane from the flour of the Palmyrah palm (Borassus flabellifer)
| Autor: | H.-U. Naegeli, Lukas Oberer, H.-J. Roth, Reto Naef, Peter Hiestand, L. La Vecchia, Laszlo Revesz |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Stereochemistry
Clinical Biochemistry Pharmaceutical Science Pharmacognosy Biochemistry Chemical synthesis Inhibitory Concentration 50 Jurkat Cells chemistry.chemical_compound Triterpene Drug Discovery Tumor Cells Cultured Humans Lymphocytes Molecular Biology Plant Proteins chemistry.chemical_classification biology Chemistry Organic Chemistry Dammarane Biological activity biology.organism_classification Borassus Triterpenes Terpenoid Models Chemical Delayed hypersensitivity Molecular Medicine Immunosuppressive Agents |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 9:1521-1526 |
| ISSN: | 0960-894X |
| Popis: | The novel triterpene 1 with a dammarane skeleton and a hitherto unknown 17ct-substitution pattern has been isolated from the Palmyrah palm in low yield and prepared by synthesis in larger quantities. 1 was shown to be an extremely potent immunosuppressant in vitro (MLR; IC5c~=10 ng/ml) and in vivo (DTH; ED~0=0.01 mg/kg p.o.). A glucocorticoid like activity is excluded. © 1999 Elsevier Science Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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