Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens
| Autor: | Ohn A. Chow, Ryan B. Camire, Zaynah N. A. Dewan, Xueping Zhu, Isaac M. Chiu, Caroline L. Sokol, Caroline Perner, Pamela A. Aderhold, Tiphaine Voisin, Cameron H. Flayer |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Sensory Receptor Cells Cellular differentiation Immunology TRPV1 Substance P Biology Type 2 immune response 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Immune system Dermis Cell Movement Ganglia Spinal medicine Hypersensitivity Immunology and Allergy Animals Dendritic cell migration Receptor Dendritic Cells Allergens Cell biology 030104 developmental biology Infectious Diseases medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis Female Biomarkers |
| Zdroj: | Immunity. 53(5) |
| ISSN: | 1097-4180 |
| Popis: | Summary Dendritic cells (DCs) of the cDC2 lineage initiate allergic immunity and in the dermis are marked by their expression of CD301b. CD301b+ dermal DCs respond to allergens encountered in vivo, but not in vitro. This suggests that another cell in the dermis may sense allergens and relay that information to activate and induce the migration of CD301b+ DCs to the draining lymph node (dLN). Using a model of cutaneous allergen exposure, we show that allergens directly activated TRPV1+ sensory neurons leading to itch and pain behaviors. Allergen-activated sensory neurons released the neuropeptide Substance P, which stimulated proximally located CD301b+ DCs through the Mas-related G-protein coupled receptor member A1 (MRGPRA1). Substance P induced CD301b+ DC migration to the dLN where they initiated T helper-2 cell differentiation. Thus, sensory neurons act as primary sensors of allergens, linking exposure to activation of allergic-skewing DCs and the initiation of an allergic immune response. |
| Databáze: | OpenAIRE |
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