Weight-based combination therapy with peginterferon alpha-2b and ribavirin for Naïve, relapser and non-responder patients with chronic hepatitis C
| Autor: | Evaldo Stanislau Affonso de Araújo, A.G. Vigani, Roberto Focaccia, Cirley Maria de Oliveira Lobato, Ricardo Vila, Andrelina Borges, Jacqueline Bittencourt Althoff Paixao, Neiva Sellan Lopes Gonçales, Maria Lúcia Corrêa-Giannella, Renata M. Perez, Heitor Rosa, Maria Lucia Gomes Ferraz, Judith Weirich, Antonio Alci Barone, Fernando L. Gonçales, Henrique Sérgio Morais Coelho, Umbeliana Barbosa de Oliveira |
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| Přispěvatelé: | Faculty of Medical Sciences of Campinas, São Paulo University School of Medicine, Emilio Ribas Institute, Federal University of Rio de Janeiro, Universidade Federal de São Paulo (UNIFESP), Secretary of Health of Acre, Federal University of Goiás, Schering-Plough Brazil, São Paulo University Medical School Laboratory of Medical Investigations |
| Rok vydání: | 2006 |
| Předmět: |
Male
lcsh:QR1-502 Hepacivirus Gastroenterology lcsh:Microbiology Polyethylene Glycols chemistry.chemical_compound Pegylated interferon Interferon Genotype Prospective Studies Depression (differential diagnoses) education.field_of_study virus diseases Middle Aged Viral Load Hepatitis C Recombinant Proteins Treatment Outcome Infectious Diseases RNA Viral Drug Therapy Combination Female medicine.drug Adult Microbiology (medical) medicine.medical_specialty Adolescent Combination therapy Population Interferon alpha-2 Antiviral Agents Drug Administration Schedule lcsh:Infectious and parasitic diseases Chronic hepatitis Internal medicine Ribavirin medicine Humans lcsh:RC109-216 education Aged therapy business.industry Body Weight Interferon-alpha Hepatitis C Chronic digestive system diseases chemistry interferon alpha-2b Immunology business |
| Zdroj: | Repositório Institucional da UNIFESP Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP Brazilian Journal of Infectious Diseases, Volume: 10, Issue: 5, Pages: 311-316, Published: OCT 2006 Brazilian Journal of Infectious Diseases, Vol 10, Iss 5, Pp 311-316 Brazilian Journal of Infectious Diseases v.10 n.5 2006 Brazilian Journal of Infectious Diseases Brazilian Society of Infectious Diseases (BSID) instacron:BSID |
| ISSN: | 1413-8670 |
| DOI: | 10.1590/s1413-86702006000500002 |
| Popis: | Combination therapy with pegylated interferon and ribavirin is considered the new standard therapy for naïve patients with chronic hepatitis C. We evaluated the efficacy and safety of treatment with weight-based peginterferon alpha-2b (1.5 mg/kg per week) plus ribavirin (800-1,200 mg/day) for 48 weeks in naïve, relapser and non-responder (to previous treatment with interferon plus ribavirin) patients with chronic hepatitis C. Sixty-seven naïve, 26 relapser and 40 non-responder patients were enrolled. The overall sustained virological response (SVR) for the intention-to-treat population was 54% for naïve, 62% for relapser and 38% for non-responder patients. In the naïve subgroup, SVR was significantly higher in patients with the non-1 genotype (67%) compared to those with genotype 1 (45%). In relapsers and non-responders, SVR was, respectively, 69% and 24% in patients with genotype 1 and 43% and 73% in those with genotype non-1. There were no significant differences in SVR rates among the three body weight ranges (< 65 kg, 65-85 kg and > 85 kg) in any of the subgroups. Early virological response (EVR) was reached by 78%, 81% and 58% of naïve, relapser and non-responder patients, respectively, and among those with EVR, 63%, 67% and 61%, respectively, subsequently achieved SVR. All of the non-responder patients who did not have EVR reached SVR. Treatment was discontinued in 13% of the patients, due to loss to follow-up, hematological abnormalities or depression. Faculty of Medical Sciences of Campinas São Paulo University School of Medicine Emilio Ribas Institute Federal University of Rio de Janeiro Federal University of São Paulo Secretary of Health of Acre Federal University of Goiás Schering-Plough Brazil São Paulo University Medical School Laboratory of Medical Investigations UNIFESP, EPM SciELO |
| Databáze: | OpenAIRE |
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