Arterial and venous thromboembolism in COVID-19: a study-level meta-analysis
| Autor: | Claire Grange, Jean-Christophe Lega, Boun Kim Tan, Laurent Bertoletti, Yesim Dargaud, Marion Douplat, Sabine Mainbourg, Steeve Provencher, Hervé Lobbes, Arnaud Friggeri |
|---|---|
| Přispěvatelé: | Hospices Civils de Lyon (HCL), Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty pulmonary embolism Coronavirus disease 2019 (COVID-19) Critical Care Deep vein [SDV]Life Sciences [q-bio] Prevalence 030204 cardiovascular system & hematology law.invention 03 medical and health sciences 0302 clinical medicine law Internal medicine Thromboembolism medicine Humans 030212 general & internal medicine business.industry COVID-19 medicine.disease Intensive care unit Thrombosis 3. Good health Pulmonary embolism Hospitalization medicine.anatomical_structure Meta-analysis viral infection business Venous thromboembolism |
| Zdroj: | Thorax Thorax, 2021, 76 (10), pp.970-979. ⟨10.1136/thoraxjnl-2020-215383⟩ Thorax, BMJ Publishing Group, 2021, 76 (10), pp.970-979. ⟨10.1136/thoraxjnl-2020-215383⟩ |
| ISSN: | 0040-6376 |
| Popis: | BackgroundThe prevalence of venous thromboembolic event (VTE) and arterial thromboembolic event (ATE) thromboembolic events in patients with COVID-19 remains largely unknown.MethodsIn this meta-analysis, we systematically searched for observational studies describing the prevalence of VTE and ATE in COVID-19 up to 30 September 2020.ResultsWe analysed findings from 102 studies (64 503 patients). The frequency of COVID-19-related VTE was 14.7% (95% CI 12.1% to 17.6%, I2=94%; 56 studies; 16 507 patients). The overall prevalence rates of pulmonary embolism (PE) and leg deep vein thrombosis were 7.8% (95% CI 6.2% to 9.4%, I2=94%; 66 studies; 23 117 patients) and 11.2% (95% CI 8.4% to 14.3%, I2=95%; 48 studies; 13 824 patients), respectively. Few were isolated subsegmental PE. The VTE prevalence was significantly higher in intensive care unit (ICU) (23.2%, 95% CI 17.5% to 29.6%, I2=92%, vs 9.0%, 95% CI 6.9% to 11.4%, I2=95%; pinteractioninteraction=0.04). The frequency rates of overall ATE, acute coronary syndrome, stroke and other ATE were 3.9% (95% CI 2.0% to to 3.0%, I2=96%; 16 studies; 7939 patients), 1.6% (95% CI 1.0% to 2.2%, I2=93%; 27 studies; 40 597 patients) and 0.9% (95% CI 0.5% to 1.5%, I2=84%; 17 studies; 20 139 patients), respectively. Metaregression and subgroup analyses failed to explain heterogeneity of overall ATE. High heterogeneity limited the value of estimates.ConclusionsPatients admitted in the ICU for severe COVID-19 had a high risk of VTE. Conversely, further studies are needed to determine the specific effects of COVID-19 on the risk of ATE or VTE in less severe forms of the disease. |
| Databáze: | OpenAIRE |
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