Impact of Gut Colonization by Antibiotic-Resistant Bacteria on the Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation: A Retrospective, Single-Center Study
| Autor: | Wieslaw Wiktor-Jedrzejczak, Patrycja Rusicka, Ewa Swoboda-Kopeć, Katarzyna Robak, Zinaida Peric, Jarosław Biliński, Halina Marchel, Grzegorz W. Basak, Ewa Karakulska-Prystupiuk, Marta Wróblewska, Kazimierz Hałaburda |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Adolescent medicine.medical_treatment Graft vs Host Disease Bacteremia Hematopoietic stem cell transplantation Gut flora Single Center Article Young Adult 03 medical and health sciences 0302 clinical medicine Antibiotic resistance Drug Resistance Bacterial medicine Humans Transplantation Homologous Colonization Aged Retrospective Studies Transplantation biology business.industry Hematopoietic Stem Cell Transplantation Gut colonization Antibiotic-resistant bacteria Bacterial Infections Hematology Middle Aged biology.organism_classification medicine.disease Survival Analysis Gastrointestinal Microbiome Treatment Outcome Hematologic Neoplasms 030220 oncology & carcinogenesis Immunology Female Stem cell business 030215 immunology |
| Zdroj: | Biology of Blood and Marrow Transplantation. 22:1087-1093 |
| ISSN: | 1083-8791 |
| DOI: | 10.1016/j.bbmt.2016.02.009 |
| Popis: | Gut colonization by antibiotic-resistant bacteria may underlie hard-to-treat systemic infections. There is also accumulating evidence on the immunomodulatory function of gut microbiota after allogeneic stem cell transplantation (alloSCT) and its impact on graft-versus-host disease (GVHD). We investigated the epidemiology and clinical impact of gut colonization after alloSCT and retrospectively analyzed data on 107 alloSCTs performed at a single transplant center. Pretransplant microbiology screening identified colonization in 31% of cases. Colonization had a negative impact on overall survival after alloSCT in univariate (34% versus 74% at 24 months, P |
| Databáze: | OpenAIRE |
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