Characterizaton of gamma delta T cells in Marek's disease virus (Gallid herpesvirus 2) infection of chickens
| Autor: | Raveendra R. Kulkarni, Shayan Sharif, Khaled Taha-Abdelaziz, Brandon L. Plattner, Leah R. Read, Adrianna Laursen |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Time Factors Palatine Tonsil Biology CD8-Positive T-Lymphocytes Virus 03 medical and health sciences Immune system Immunity Virology Gene expression Marek Disease Gallid herpesvirus Animals Cecum Herpesvirus 2 Gallid Intraepithelial Lymphocytes Poultry Diseases Marek's disease Host (biology) Gene Expression Profiling biology.organism_classification 3. Good health 030104 developmental biology Cytokines Chickens CD8 Spleen |
| Zdroj: | Virology. 522 |
| ISSN: | 1096-0341 |
| Popis: | Immunity against Marek's disease (MD), caused by Gallid herpesvirus 2 (GaHV-2), in chickens is mediated by both innate and adaptive responses. The present study evaluated the effects of GaHV-2 infection on distribution and frequency of γδ T cells in tissues, as well as their expression of cytokines. We found that the infected chickens had significantly higher number of γδ T cells in their spleens by 10 and 21 days post-infection (d.p.i.) and nearly 100% of these γδ T cells were CD8+ at 21 d.p.i. Conversely, the number of γδ T cells in the cecal tonsils of GaHV-2-infected birds decreased compared to uninfected birds. Splenic γδ T cells had up-regulated expression of interferon-γ early in infection followed by simultaneous gene expression of interleukin-10 during the later phases. In conclusion, these results suggest a potential role for γδ T cells in host response to GaHV-2 and further elucidate the underlying immunological mechanisms of interactions between this virus and its host. |
| Databáze: | OpenAIRE |
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