Chemo/radiotherapy-Induced Bone Marrow Niche Alterations
| Autor: | Mohammad Ghasemi Dehcheshmeh, Najmaldin Saki, Niloofar Farshchi, Hassan Rafieemehr, Masumeh Maleki Behzad, Saeed Azandeh |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research Stromal cell Medullary cavity medicine.medical_treatment Cell Biology 03 medical and health sciences 0302 clinical medicine Bone Marrow Neoplasms medicine Humans Gene Regulatory Networks Stem Cell Niche Mesenchymal stem cell Cell Differentiation General Medicine Hematopoietic Stem Cells Hematopoiesis Gene Expression Regulation Neoplastic Radiation therapy stomatognathic diseases Haematopoiesis 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Cancer research Bone marrow Stem cell Signal Transduction |
| Zdroj: | Cancer Investigation. :1-15 |
| ISSN: | 1532-4192 0735-7907 |
| DOI: | 10.1080/07357907.2020.1855353 |
| Popis: | Bone marrow (BM) niche is a specific microenvironment for hematopoietic stem cells (HSCs) as well as non-hematopoietic cells. Evidence shows that chemo/radiotherapy can lead to the disruption of different properties of HSCs such as proliferation, differentiation, localization, self-renewa, and steady-state of cell populations. Investigations have shown that the deregulation of balance within the marrow cavity due to chemo/radiotherapy could lead to bone loss, abnormal hematopoiesis, and enhanced differentiation potential of mesenchymal stem cells towards the adipogenic lineage. Therefore, understanding the underlying mechanisms of chemo/radiotherapy induced BM niche changes may lead to the application of appropriate therapeutic agents to prevent BM niche defects. Highlights Chemo/radiotherapy disrupts the steady-state of bone marrow niche cells and result in deregulation of normal balance of stromal cell populations. Chemo/radiotherapy agents play a significant role in reducing of bone formation as well as fat accumulation in the bone marrow niche. Targeting molecular pathways may lead to recovery of bone marrow niches after chemo/radiotherapy. |
| Databáze: | OpenAIRE |
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