The Immunoscore in Localized Urothelial Carcinoma Treated with Neoadjuvant Chemotherapy: Clinical Significance for Pathologic Responses and Overall Survival
| Autor: | Roubini Zakopoulou, Aristotelis Bamias, Marie Auvray, Philippe Camparo, Xavier Barthere, Mostefa Bennamoun, Daniela Bruni, Pierre Colin, Isabelle Boquet, Jérôme Galon, Gabriela Bindea, Elise F. Nassif, François Audenet, Virginie Verkarre, Bernhard Mlecnik, Alexandre Colau, Bruno d’Acremont, Aurelie Catteau, Stéphane Oudard, Marine Martel, Marine Lefevre, Arnaud Mejean, Eva Comperat, Aurelie Fugon, Constance Thibault |
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| Přispěvatelé: | Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Inovarion, Groupe Hospitalier Diaconesses Croix Saint-Simon, Institut Mutualiste de Montsouris (IMM), Clinique Saint Jean de Dieu, Gestionnaire, Hal Sorbonne Université, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_specialty medicine.medical_treatment Immunoscore [SDV]Life Sciences [q-bio] lcsh:RC254-282 Gastroenterology Article predictive response to chemotherapy Cystectomy 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Clinical significance immuno-oncology urothelial carcinoma Chemotherapy Bladder cancer business.industry Retrospective cohort study lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease prognostic score 3. Good health [SDV] Life Sciences [q-bio] 030104 developmental biology Oncology 030220 oncology & carcinogenesis Cohort Biomarker (medicine) business CD8 neoadjuvant chemotherapy |
| Zdroj: | Cancers Cancers, MDPI, 2021, 13 (3), pp.494. ⟨10.3390/cancers13030494⟩ Volume 13 Issue 3 Cancers, Vol 13, Iss 494, p 494 (2021) |
| ISSN: | 2072-6694 |
| DOI: | 10.3390/cancers13030494⟩ |
| Popis: | (1) Background&mdash The five-year overall survival (OS) of muscle-invasive bladder cancer (MIBC) with neoadjuvant chemotherapy and cystectomy is around 50%. There is no validated biomarker to guide the treatment decision. We investigated whether the Immunoscore (IS) could predict the pathologic response to neoadjuvant chemotherapy and survival outcomes. (2) Methods&mdash This retrospective study evaluated the IS in 117 patients treated using neoadjuvant chemotherapy for localized MIBC from six centers (France and Greece). Pre-treatment tumor samples were immunostained for CD3+ and CD8+ T cells and quantified to determine the IS. The results were associated with the response to neoadjuvant chemotherapy, time to recurrence (TTR), and OS. (3) Results&mdash Low (IS-0), intermediate (IS-1&ndash 2), and high (IS-3&ndash 4) ISs were observed in 36.5, 43.7, and 19.8% of the cohort, respectively. IS was positively associated with a pathologic complete response (pCR p-value = 0.0096). A high IS was found in 35.7% of patients with a pCR, whereas it was found in 11.3% of patients without a pCR. A low IS was observed in 48.4% of patients with no pCR and in 21.4% of patients with a pCR. Low-, intermediate-, and high-IS patients had five-year recurrence-free rates of 37.2%, 36.5%, and 72.6%, respectively. In the multivariable analysis, a high IS was associated with a prolonged TTR (high vs. low: p = 0.0134) and OS (high vs. low: p = 0.011). (4) Conclusions&mdash This study showed the significant prognostic and predictive roles of IS regarding localized MIBC. |
| Databáze: | OpenAIRE |
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