Gastroduodenal Symptoms in Inflammatory Bowel Disease Are Correlated with Gastric Emptying and Serum Levels of Active Ghrelin
| Autor: | Kamila Maria Oliveira Sales, Miguel Angelo N. Souza, Renan Frota Cavalcanti, Lucia L. B. C. Braga, Larissa Gurgel Mota Saraiva, M. Castro, Marcellus H.L.P. Souza, Ricardo Brandt de Oliveira |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Leptin Male medicine.medical_specialty Duodenum ENTEROPATIAS INFLAMATÓRIAS Epigastric pain Gastroenterology Inflammatory bowel disease Internal medicine medicine Humans Aged Breath test Carbon Isotopes Gastric emptying medicine.diagnostic_test business.industry Stomach digestive oral and skin physiology General Medicine Middle Aged Inflammatory Bowel Diseases medicine.disease Ghrelin digestive system diseases Pathophysiology Breath Tests Gastric Emptying Case-Control Studies Vomiting Female Caprylates medicine.symptom business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1421-9875 0257-2753 |
| DOI: | 10.1159/000494920 |
| Popis: | Background: Inflammatory bowel disease (IBD) is associated with delay in gastric emptying, increase in ghrelin, and decrease in leptin. The aim was to investigate the correlation between gastroduodenal (GD) symptoms, gastric emptying, and serum levels of active ghrelin and leptin in IBD. Twenty-seven IBD patients and 26 healthy volunteers were asked to complete the Porto Alegre Dyspeptic Symptoms Questionnaire. A gastric emptying test for solids was performed using a C13 octanoic acid breath test. During this test, serum samples were collected for measuring active ghrelin and leptin concentrations by radioimmunoassay. Summary: Patients with IBD demonstrated delayed gastric emptying compared with healthy volunteers. In patients with GD symptoms, the delay in gastric emptying was more pronounced, and there were significant correlations of satiety and vomiting with gastric emptying. Basal leptin, but not active ghrelin, increased in patients with GD symptoms compared with patients without these symptoms. There were negative correlations between basal active ghrelin with total Porto Alegre score and epigastric pain in IBD patients with GD symptoms. Key Messages: In IBD, satiety and vomiting were associated with delay in gastric emptying. Conversely, epigastric pain had a negative correlation with active ghrelin. Our results suggest that different pathophysiological mechanisms contribute to GD symptoms in IBD. |
| Databáze: | OpenAIRE |
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