Genetic Polymorphisms in Pre-microRNAs and Risk of Ischemic Stroke in a Chinese Population
| Autor: | Bo Zhang, Shun-Xian Wang, Yun Liu, Ying Ma, Ju-Ming Yu, Xiaoming Wang |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
Oncology medicine.medical_specialty Neurology Genotype Single-nucleotide polymorphism Polymorphism Single Nucleotide Brain Ischemia Pathogenesis Cellular and Molecular Neuroscience Asian People Gene Frequency Risk Factors Internal medicine Genetic model medicine Genetic predisposition Humans Genetic Predisposition to Disease Allele Aged Genetics business.industry Heterozygote advantage General Medicine Middle Aged Stroke MicroRNAs Case-Control Studies Female business |
| Zdroj: | Journal of Molecular Neuroscience. 52:473-480 |
| ISSN: | 1559-1166 0895-8696 |
| Popis: | Ischemic stroke is considered to be a complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. MicroRNAs participated in various physiopathological processes; common single-nucleotide polymorphisms (SNPs) in pre-miRNAs have been shown to be associated with susceptibility to several human diseases. We evaluated the associations of the hsa-mir-196-a2/rs11614913 T/C, hsa-mir-146a/rs2910164 C/G, and hsa-mir-499/rs3746444 A/G polymorphisms in pre-miRNAs with the risk of ischemic stroke in a Chinese population. The three polymorphisms were identified in 296 ischemic stroke patients and 391 healthy controls using polymerase chain reaction–restriction fragment length polymorphism. The frequency of the allele G of hsa-mir-499/rs3746444 A/G showed significant association with ischemic stroke when compared with controls (OR = 1.509, 95%CI = 1.151–1.978, P = 0.003). Increased ischemic stroke risks were associated with rs3746444 A/G genotypes in different genetic model (homozygote comparison: P = 0.045, OR = 2.084, 95%CI = 1.019–4.262; heterozygote comparison: P = 0.024, OR = 1.489, 95%CI = 1.063–2.087; dominant genetic model: P = 0.007, OR = 1.563, 95%CI = 1.135–2.153). Similar results were obtained by adjusted fully risk factors. However, we failed to find any association between the alleles and genotypes of rs2910164 C/G and rs11614913 T/C SNPs and ischemic stroke, respectively (p > 0.05). The present study provided evidence that hsa-mir-499/rs3746444 A/G polymorphism might be associated with a significantly increased risk of ischemic stroke in a Chinese population, indicating that the common genetic polymorphism in pre-microRNAs contributed to the pathogenesis of ischemic stroke. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink