Carcinoid heart disease. Correlation of high serotonin levels with valvular abnormalities detected by cardiac catheterization and echocardiography
| Autor: | Harrison Jk, Paul A. Robiolio, Jerome M. Feldman, Vera H. Rigolin, John S. Wilson, L. L. Sanders, Thomas M. Bashore |
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| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty Cardiac Catheterization Serotonin Heart disease medicine.medical_treatment Heart Valve Diseases Carcinoid Heart Disease Coronary Disease Physiology (medical) Internal medicine Medicine Humans Heart valve Prospective Studies Cardiac catheterization Heart Failure business.industry medicine.disease Survival Analysis medicine.anatomical_structure Echocardiography Heart failure Heart catheterization cardiovascular system Cardiology Female Cardiology and Cardiovascular Medicine business Carcinoid syndrome |
| Zdroj: | Circulation. 92(4) |
| ISSN: | 0009-7322 |
| Popis: | Background Although serotonin has been postulated as an etiologic agent in the development of carcinoid heart disease, no direct evidence for different ambient serotonin levels in cardiac and noncardiac patients has been reported to date. Methods and Results The present study reviews our experience with 604 patients in the Duke Carcinoid Database. Nineteen patients with proven carcinoid heart disease (by cardiac catheterization and/or echocardiogram) were compared with the remaining 585 noncardiac patients in the database with regard to circulating serotonin and its principal metabolite, 5-hydroxyindole acetic acid (5-HIAA). No significant demographic differences existed between the cardiac and noncardiac groups; however, typical carcinoid syndrome symptoms (ie, flushing and diarrhea) were almost threefold more common in the cardiac group ( P P Conclusions These data suggest that serotonin plays a major role in the pathogenesis of the cardiac plaque formation observed in carcinoid patients. |
| Databáze: | OpenAIRE |
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