Clinicopathological features of sporadic MSI colorectal cancer and Lynch syndrome: a single-center retrospective cohort study
| Autor: | Tatsuro Yamaguchi, Yujiro Nakayama, Ekumi Kojika, Shinichiro Horiguchi, Tsunekazu Hishima, Koichi Koizumi, Akinari Takao, Takuhiko Inokuchi, Misato Takao, Takeru Iijima |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Oncology congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Colorectal cancer Single Center MLH1 03 medical and health sciences 0302 clinical medicine Surgical oncology Internal medicine Medicine Humans neoplasms Survival rate Retrospective Studies business.industry nutritional and metabolic diseases Microsatellite instability Retrospective cohort study Hematology General Medicine medicine.disease Colorectal Neoplasms Hereditary Nonpolyposis digestive system diseases Lynch syndrome 030104 developmental biology 030220 oncology & carcinogenesis Colonic Neoplasms Surgery Microsatellite Instability business Colorectal Neoplasms |
| Zdroj: | International journal of clinical oncology. 26(10) |
| ISSN: | 1437-7772 |
| Popis: | The clinical and pathological features of sporadic microsatellite instability-high (MSI) colorectal cancer (CRC) are still unclear. The present study aimed to clarify the clinicopathological features of sporadic MSI CRC in comparison with those of Lynch syndrome (LS) exploratorily. The present study was a single-center, retrospective cohort study. Sporadic MSI CRC was defined as MSI CRC with aberrant promoter hypermethylation of the MLH1 gene, while hereditary MSI CRC was defined colorectal cancer in patients with LS. In total, 2653 patients were enrolled; of these, 120 (4.5%) had MSI CRC, 98 had sporadic MSI CRC, and 22 had LS. Patients with sporadic MSI CRC were significantly older (p |
| Databáze: | OpenAIRE |
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