Potent HIV protease inhibitors incorporating high-affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere
| Autor: | John F. Kincaid, Jim Buthod, Wonhwa Cho, Clare Rudall, Arun K. Ghosh, Hanna Cho, Louis E. Holland, Yumee Koo, D. Eric Walters, Khaja Azhar Hussain, K. Krishnan |
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| Rok vydání: | 1998 |
| Předmět: |
Stereochemistry
Isostere Clinical Biochemistry Pharmaceutical Science Ligands Biochemistry Chemical synthesis Cell Line Drug Discovery Humans HIV Protease Inhibitor Molecular Biology Saquinavir chemistry.chemical_classification Sulfonamides biology Organic Chemistry HIV Protease Inhibitors In vitro Sulfonamide Enzyme Models Chemical chemistry Enzyme inhibitor Drug Design Benzene derivatives biology.protein Molecular Medicine |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 8:687-690 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(98)00098-5 |
| Popis: | Design and synthesis of a series of very potent nonpeptide HIV protease inhibitors are described. The inhibitors are derived from novel high affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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