Adolescent and adult lymphoblastic leukaemia: Prognostic factors and response to treatment
| Autor: | J.R. Allen, J. W. Hamer, G. G. Fraser, D. C. Heaton, Derek N.J. Hart, M. E. J. Beard |
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| Rok vydání: | 1985 |
| Předmět: |
Adult
Male Risk Cancer Research Pediatrics medicine.medical_specialty Adolescent medicine.medical_treatment Philadelphia chromosome Acute lymphocytic leukemia Humans Medicine Aged Retrospective Studies Chemotherapy business.industry Age Factors Complete remission Mediastinal mass Hematology General Medicine Middle Aged Prognosis medicine.disease Combined Modality Therapy Response to treatment Leukemia Lymphoid Oncology Lymphoblastic leukaemia Drug Therapy Combination Female business Median survival |
| Zdroj: | Hematological Oncology. 3:211-216 |
| ISSN: | 1099-1069 0278-0232 |
| DOI: | 10.1002/hon.2900030310 |
| Popis: | Thirty consecutive patients with acute lymphoblastic leukaemia (ALL) who received treatment at Christchurch Hospital between 1972 and 1982 were reviewed. Complete remission (CR) was achieved in 80 per cent with a median survival of 65 weeks. Eleven of 30 patients had one or more of the following features—B cell ALL, a mediastinal mass, the Philadelphia chromosome (Ph1) and age 60 years or older at diagnosis. Although CR was obtained in 8 of these patients none survived three years. The remaining 19 patients were regarded as ‘good risk’ and treated by moderate intensity chemotherapy schedules. CR was obtained in 16 of these patients (84 per cent) and the estimated 5 year survival was 62 per cent with 6 patients remaining in remission from 5 to 9 years from diagnosis. These results demonstrate the value of objective and reproducible clinical and laboratory findings in defining a subset of ALL patients which may not require high intensity chemotherapy schedules. |
| Databáze: | OpenAIRE |
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