Development of the Terumo Capiox Centrifugal Pump and Its Clinical Application to Open Heart Surgery: A Comparative Study with the Roller Pump
| Autor: | Toshihiko Kijima, Hiromichi Fukasawa, Hitoshi Koyanagi, Chisato Nojiri, Hiroaki Oshiyama, Hayao Nakatani, Fumitaka Yamaki, Masahiro Endo, Tetsuzo Akutsu, Kunio Horiuchi, Hiroshi Nishida |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Biomedical Engineering Medicine (miscellaneous) Hemodynamics Peristaltic pump Bioengineering In Vitro Techniques Hemolysis law.invention Biomaterials Hemoglobins law Free plasma hemoglobin Cardiopulmonary bypass Animals Humans Medicine Coronary Artery Bypass Cardiopulmonary Bypass Platelet Count business.industry Equipment Design General Medicine Middle Aged beta-Thromboglobulin Centrifugal pump Surgery medicine.anatomical_structure Beta-thromboglobulin Anesthesia Circulatory system Cattle Female Heart-Assist Devices business Artery |
| Zdroj: | Artificial Organs. 17:323-327 |
| ISSN: | 1525-1594 0160-564X |
| Popis: | We have developed the Terumo Capiox centrifugal pump (CXP), which consists of a rotor having a unique straight-path design to reduce pump rotational speed without decreasing hydraulic efficiency. The CXP was tested in vitro for blood trauma with a specially designed test circuit using fresh bovine blood. The Biopump (BP) (Medtronic, Minneapolis, MN, U.S.A.) and the roller pump (RP) were used as controls. The CXP demonstrated the smallest elevation of free plasma hemoglobin compared with the BP and the RP. The CXP was then applied to cardiopulmonary bypass (CPB) in 10 patients (CXP group) who underwent elective coronary artery bypass grafting (CABG), and the results were compared with those for a comparable roller pump group (RP group). Free plasma hemoglobin level, platelet count, and serum beta-thromboglobulin (beta-TG) level were measured during CPB. There were no CXP-related complications nor hemodynamic abnormalities during CPB. The CXP group demonstrated less hemolysis and less platelet depletion than the RP group. Furthermore, the serum beta-TG level was significantly lower in the CXP group than in the RP group. The CXP showed excellent hemodynamic performance with less blood trauma both in vitro and in clinical application to open heart surgery. Thus, the CXP has significant potential to be safely applied to CPB for open heart surgery and circulatory support. |
| Databáze: | OpenAIRE |
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